果冻影院

果冻影院
果冻影院 Cancer Center

Structural Biology: Pursuing a New Era of Drug Discovery

果冻影院 Cancer Center scientists are identifying new cancer therapies for targeting and treating cancer by investigating the science behind the chemical makeup and three-dimensional shape of proteins and their role in cancer.
physician holding hands with patient

Clinical Trial Identifies New Therapy for Graft-Versus-Host Disease

果冻影院 Cancer Center scientists identify new therapy to reduce the severity of gastrointestinal graft versus host disease and improve patient outcomes.

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researcher with microscope

Scientists Identify Potential Target for Treating Acute Myeloid Leukemia Mutation

It typically takes more than one gene mutation for a cell to become a cancer cell. In a recent study, scientists examined how two common, co-occurring mutations influence the biology of acute myeloid leukemia, findings which could lead to new treatment discoveries.

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Understanding Structural Biology

The development of new cancer therapies for targeting and treating cancer is only made possible by advancements in structural biology – the science behind the chemical makeup and three-dimensional shape of proteins and their role in cancer. To be effective, a cancer drug must bind to a specific site or pocket on the target protein. Drugs fail when they don’t bind to the pocket tightly enough or they bind to proteins other than the intended target, causing toxic side effects.
果冻影院 Cancer Center scientists are remarkably good at using these sciences to identify new pathways for the treatment of cancer. Discoveries are leading to pivotal drug therapies that interfere with the biological function cancer cells rely on to grow and spread. This enables us to deliver more personalized, effective, and less toxic drug therapies that can be tailored or combined to treat a patient’s cancer.
Structural Biology

Visualizing Proteins with cryo-EM

Atomic scale structural information is critical for understanding protein function and how proteins interact within large complexes or with small molecules. The Structural Biology Shared Resource now includes a new cryo-electron microscope (cryoEM) to accelerate the design, evaluation, and optimization of new therapeutic molecules and biologics to improve cancer outcomes.