果冻影院

果冻影院
果冻影院 Cancer Center

Cell Therapy (CTSR)

The Cell Therapy Shared Resource provides state-of-the-art production and processing of cell therapy products, innovative on-site CAR-T cell manufacturing and processing, and immuno-oncology consulting services, access to instrumentation for immune profiling and monitoring, and educational workshops.

Scheduling, Location, and Hours of Operation

Pavilion Building | Monday–Friday, 7 a.m.-6 p.m.
Extended hours are available for time-sensitive patient care needs. Questions? Contact celltherapyresearch@mcw.edu.

Services and Technologies

The CTSR provides initial project, clinical trial, and grant consultation services, free of charge, to help users understand the technical aspects, advantages, limitations, turnaround time, and cost of services.

View the FY25 CTSR price sheet (PDF)

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Standard-of-care Clinical Processing
  • Hematopoietic stem cell processing including CD34+ selection
Cell Processing and Product Manufacturing
  • Onsite CAR-T cell manufacturing under FDA-approved IND (Miltenyi Biotec CliniMACS Prodigy)
  • α/β T cell-depletion of HSC products
Immune Profiling
  • Single-cell functional & phenotypic (Bruker Lightning)
  • Single-cell cytokine analysis (IsoPlexis IsoLight)
  • Multiplexed cytokine quantification (Luminex)
  • Real-time cytotoxicity assays (xCelligence)
  • Digital droplet PCR, ELISPOT, and ELISA
  • Flow cytometry (Miltenyi MACSQuant10)
Lymphoma Cells

iLab Requests and Support

Access the links below to learn how to register for iLab and submit requests.

Leadership

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Peiman Hematti, MD

Director, Cell Therapy Shared Resource (CTSR)

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Tyce Kearl, MD, PhD

Co-Director, Cell Therapy Laboratory Shared Resource

tkearl@mcw.edu

View Profile

Notable Publications

(Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Transl Oncol 2024 Apr;42:101899 PMID: 38320395 PMCID: PMC10851216 DOI: 10.1016/j.tranon.2024.101899 SCOPUS ID: 2-s2.0-85184507548 02/07/2024

 (Chung DJ, Shah N, Wu J, Logan B, Bisharat L, Callander N, Cheloni G, Anderson K, Chodon T, Dhakal B, Devine S, Somaiya Dutt P, Efebera Y, Geller N, Ghiasuddin H, Hematti P, Holmberg L, Howard A, Johnson B, Karagkouni D, Lazarus HM, Malek E, McCarthy P, McKenna D, Mendizabal A, Nooka A, Munshi N, O'Donnell L, Rapoport AP, Reese J, Rosenblatt J, Soiffer R, Stroopinsky D, Uhl L, Vlachos IS, Waller EK, Young JW, Pasquini MC, Avigan D) Clin Cancer Res 2023 Dec 01;29(23):4784-4796. DOI: 10.1158/1078-0432.CCR-23-0235. PMID: 37463058; PMCID: PMC10690096 SCOPUS ID: 2-s2.0-85178651085 07/18/23

(Bolaños-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, Elmariah H, Rezvani AR, Gooptu M, Larkin KT, Shaffer BC, El Jurdi N, Loren AW, Solh M, Hall AC, Alousi AM, Jamy OH, Perales MA, Yao JM, Applegate K, Bhatt AS, Kean LS, Efebera YA, Reshef R, Clark W, DiFronzo NL, Leifer E, Horowitz MM, Jones RJ, Holtan SG, BMT CTN 1703 Investigators) N Engl J Med 2023 Jun 22;388(25):2338-2348 PMID 37342922 PMCID: PMC10575613 SCOPUS ID: 2-s2.0-85164529275 6/21/2023

(Chu Y, Milner J, Lamb M, Maryamchik E, Rigot O, Ayello J, Harrison L, Shaw R, Behbehani GK, Mardis ER, Miller K, Prakruthi Rao Venkata L, Chang H, Lee D, Rosenthal E, Kadauke S, Bunin N, Talano JA, Johnson B, Wang Y, Cairo MS) J Infect Dis 2023 Mar 28;227(6):788-799 PMID: 36583990 DOI: 10.1093/infdis/jiac500 SCOPUS ID: 2-s2.0-85151044080 12/31/2022

 (Knight JM, Hackett E, Szabo A, Wu R, Sauber G, Johnson B, Cusatis RN, Aughey E, Cole SW, Hillard CJ, Shah NN) Haematologica 2023 Feb 01;108(2):588-593 PMID: 36200427 PMCID: PMC9890001 SCOPUS ID: 2-s2.0-85147234722 10/07/2022

 (Zurko JC, Fenske TS, Johnson BD, Bucklan D, Szabo A, Xu H, Chaney K, Hamadani M, Hari P, Shah NN) Am J Hematol 2022 Dec;97(12):1580-1588 PMID: 36068950 DOI: 10.1002/ajh.26718 Scopus ID: 2-s2.0-85138335080 9/08/2022

 (Pulsipher MA, Ahn KW, Bunin NJ, Lalefar N, Anderson E, Flower A, Cairo MS, Talano JA, Chaudhury S, Kitko CL, Duke JL, Monos D, Leung W, Dvorak CC, Abdel-Azim H) Blood 2022 Dec 15;140(24):2556-2572 PMID: 35776909 PMCID: PMC9918850 SCOPUS ID: 2-s2.0-85144585749 7/02/2022

(Dong J, Garacci Z, Buradagunta CS, D'Souza A, Mohan M, Cunningham A, Janz S, Dhakal B, Thrift AP, Hari P) Blood Cancer J. 2022 Feb 24;12(2):34 PMID: 35210395 PMCID: PMC8873507 SCOPUS ID: 2-s2.0-85125303734 2/26/2022

(Shaw BE, Jimenez-Jimenez AM, Burns LJ, Logan BR, Khimani F, Shaffer BC, Shah NN, Mussetter A, Tang XY, McCarty JM, Alavi A, Farhadfar N, Jamieson K, Hardy NM, Choe H, Ambinder RF, Anasetti C, Perales MA, Spellman SR, Howard A, Komanduri KV, Luznik L, Norkin M, Pidala JA, Ratanatharathorn V, Confer DL, Devine SM, Horowitz MM, Bolaños-Meade J) J Clin Oncol 2021 Jun 20;39(18):1971-1982 PMID 33905264 PMCID: PMC8260905 SCOPUS ID: 2-s2.0-85108386444 4/28/2021

(Shah NN, Johnson BD, Schneider D, Zhu F, Szabo A, Keever-Taylor CA, Krueger W, Worden AA, Kadan MJ, Yim S, Cunningham A, Hamadani M, Fenske TS, Dropuli膰 B, Orentas R, Hari P) Nat Med 2020 Oct;26(10):1569-1575 PMID: 33020647 DOI: 10.1038/s41591-020-1081-3 SCOPUS ID: 2-s2.0-85092105030 10/07/2020