果冻影院

果冻影院
果冻影院 Cancer Center

Translational Metabolomics Shared Resource (TraMSR)

The Translational Metabolomics Shared Resource (TraMSR) uses advanced analytical techniques to uncover molecular changes that drive cancer development and progression. These insights enable new strategies for cancer prevention, early detection, and offer personalized treatment plans for patients.

Scheduling, Location, and Hours of Operation

Mass Spectrometry: Translational and Biomedical Research Center, 2nd floor
Redox and Bioenergetics: MACC Fund Research Center, 2nd floor
Preclinical and Clinical Imaging: Medical Imaging Research Center, 1st floor
Monday–Friday from 8 a.m.-5 p.m.

Services and Technologies

The TraMSR advances cancer research by identifying, quantifying, and imaging molecular metabolic profiles of cancer cells and tumors. Combining expertise in mass spectrometry and bioenergetics, preclinical imaging, and clinical trial response assessment using artificial intelligence (AI), TraMSR supports both preclinical research and patient monitoring in clinical trials.

View the FY25 TraMSR price sheet

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Mass Spectrometry
  • MS sample preparation
  • MS instrumentation: Bruker timsTOF Flex MALDI imaging; Thermo Exploris 240, Waters XEVO
  • MS-based omics analysis: lipidomics, glycomics, glycoproteomics, metabolomics
Redox and Bioenergetics
  • Redox: ROS measurements; GSH/GSSG measurements; redox immunoblotting
  • Metabolism: metabolic pathway profiling; mitochondrial oxygen consumption; glycolytic function; mitochondrial membrane potential; metabolic reprogramming
  • Instrumentation: Agilent Seahorse extracellular flux analyzers; HPLC and UHPLC systems; electron paramagnetic resonance (EPR) and luminescence spectrometers
Preclinical Imaging
  • IVIS SpectrumCT: small animal bioluminescence and fluorescence, low dose X ray microCT and Cherenkov Luminescence imaging
  • Small animal near-infrared (NIR) and short-wave infrared imaging (SWIR)
Clinical Imaging
  • Patient tumor and lymph node measurements and volumetrics
  • Clinical trial level reporting and audit support
  • Cloud-based image repository and tools
Biomedical Imaging Shared Resource

iLab Requests and Support

Access the links below to learn how to register for iLab and submit requests.

Leadership

headshot

Karin Hoffmeister, MD

Director, Translational Metabolomics Shared Resource (TraMSR)

khoffmeister@mcw.edu

View Profile

Notable Publications

(Bobholz SA, Hoefs A, Hamburger J, Lowman AK, Winiarz A, Duenweg SR, Kyereme F, Connelly J, Coss D, Krucoff M, Banerjee A, LaViolette PS) J Neurooncol 2024 Apr;167(2):243. PMID: 38498261; PMCID: PMC11023959; DOI: 10.1007/s11060-024-04641-2; Scopus ID: 2-s2.0-85187929260

(Pant T, Uche N, Juric M, Zielonka J, Bai X) Redox Biol 2024 Apr;70:103077. PMID: 38359749; PMCID: PMC10877431; DOI: 10.1016/j.redox.2024.103077; Scopus ID: 2-s2.0-85185554817

(Bobholz SA, Lowman AK, Connelly JM, Duenweg SR, Winiarz A, Nath B, Kyereme F, Brehler M, Bukowy J, Coss D, Lupo JM, Phillips JJ, Ellingson BM, Krucoff MO, Mueller WM, Banerjee A, LaViolette PS) Neurosurgery 2024 Mar 19. PMID: 38501824; DOI: 10.1227/neu.0000000000002898

(Sørensen M, Pershagen G, Thacher JD, Lanki T, Wicki B, Röösli M, Vienneau D, Cantuaria ML, Schmidt JH, Aasvang GM, Al-Kindi S, Osborne MT, Wenzel P, Sastre J, Fleming I, Schulz R, Hahad O, Kuntic M, Zielonka J, Sies H, Grune T, Frenis K, Münzel T, Daiber A) Redox Biol 2024 Feb;69:102995. PMID: 38142584; PMCID: PMC10788624; DOI: 10.1016/j.redox.2023.102995; Scopus ID: 2-s2.0-85180606610

 (Duenweg SR, Brehler M, Lowman AK, Bobholz SA, Kyereme F, Winiarz A, Nath B, Iczkowski KA, Jacobsohn KM, LaViolette PS) Lab Invest 2023 Dec;103(12):100269. PMID: 37898290; PMCID: PMC10872376; DOI: 10.1016/j.labinv.2023.100269; Scopus ID: 2-s2.0-85181176849

(Duenweg SR, Bobholz SA, Barrett MJ, Lowman AK, Winiarz A, Nath B, Stebbins M, Bukowy J, Iczkowski KA, Jacobsohn KM, Vincent-Sheldon S, LaViolette PS) Cancers (Basel) 2023 Sep 06;15(18). PMID: 37760407; PMCID: PMC10526331; DOI: 10.3390/cancers15184437; Scopus ID: 2-s2.0-85172781879

(Uche N, Dai Q, Lai S, Kolander K, Thao M, Schibly E, Sendaydiego X, Zielonka J, Benjamin IJ) Antioxidants (Basel) 2023 Aug 09;12(8). PMID: 37627583; PMCID: PMC10451268; DOI: 10.3390/antiox12081585; Scopus ID: 2-s2.0-85169136890

 (Cheng G, Hardy M, Kalyanaraman B) Sci Rep 2023 May 04;13(1):7254. PMID: 37142668; PMCID: PMC10160116; DOI: 10.1038/s41598-023-34266-w; Scopus ID: 2-s2.0-85158068757

 (Wang B, Wang X, Kenneth A, Drena A, Pacheco A, Kalvin L, Ibrahim ES, Rossi PJ, Thatcher K, Lincoln J) Biofabrication 2023 Jan 30;15(2). PMID: 36626826; DOI: 10.1088/1758-5090/acb1da; Scopus ID: 2-s2.0-85147095444

(Chhabra S, Szabo A, Clurman A, McShane K, Waters N, Eastwood D, Samanas L, Fei T, Armijo G, Abedin S, Longo W, Hari P, Hamadani M, Shah NN, Runaas L, Jerkins JH, Van den Brink M, Peled JU, Drobyski WR) Haematologica 2023 Jan 01;108(1):250-256. PMID: 36106394; PMCID: PMC9827178; DOI: 10.3324/haematol.2022.281309; Scopus ID: 2-s2.0-85145424654

 (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB) iScience 22 December 2022;25(12). DOI: 10.1016/j.isci.2022.105670; Scopus ID: 2-s2.0-85143723525

(Chhabra S, Visotcky A, Pasquini MC, Zhu F, Tang X, Zhang MJ, Thompson R, Abedin S, D'Souza A, Dhakal B, Drobyski WR, Fenske TS, Jerkins JH, Rizzo JD, Runaas L, Saber W, Shah NN, Shaw BE, Horowitz MM, Hari PN, Hamadani M) [Biology of Blood and Marrow Transplantation 26/10 (2020) 1876-1885, (S1083879120304146), (10.1016/j.bbmt.2020.07.005)] Transplantation and Cellular Therapy October 2022;28(10):717. PMID: 36202527; DOI: 10.1016/j.jtct.2021.01.005; Scopus ID: 2-s2.0-85101258094

(McGarry SD, Brehler M, Bukowy JD, Lowman AK, Bobholz SA, Duenweg SR, Banerjee A, Hurrell SL, Malyarenko D, Chenevert TL, Cao Y, Li Y, You D, Fedorov A, Bell LC, Quarles CC, Prah MA, Schmainda KM, Taouli B, LoCastro E, Mazaheri Y, Shukla-Dave A, Yankeelov TE, Hormuth DA 2nd, Madhuranthakam AJ, Hulsey K, Li K, Huang W, Huang W, Muzi M, Jacobs MA, Solaiyappan M, Hectors S, Antic T, Paner GP, Palangmonthip W, Jacobsohn K, Hohenwalter M, Duvnjak P, Griffin M, See W, Nevalainen MT, Iczkowski KA, LaViolette PS) J Magn Reson Imaging 2022 Jun;55(6):1745-1758. PMID: 34767682; PMCID: PMC9095769; DOI: 10.1002/jmri.27983; Scopus ID: 2-s2.0-85118887092

 (Huang M, Xiong D, Pan J, Zhang Q, Wang Y, Myers CR, Johnson BD, Hardy M, Kalyanaraman B, You M) Adv Sci (Weinh) 2022 Apr;9(12):e2101267. PMID: 35243806; PMCID: PMC9036031; Scopus ID: 2-s2.0-85125564839 

 (Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P) Cancer Res 2021 Oct 15;81(20):5336-5352. PMID: 34380633; PMCID: PMC8530981; Scopus ID: 2-s2.0-85116424540

 (Javle M, Borad MJ, Azad NS, Kurzrock R, Abou-Alfa GK, George B, Hainsworth J, Meric-Bernstam F, Swanton C, Sweeney CJ, Friedman CF, Bose R, Spigel DR, Wang Y, Levy J, Schulze K, Cuchelkar V, Patel A, Burris H) Lancet Oncol 2021 Sep;22(9):1290-1300. PMID: 34339623; DOI: 10.1016/S1470-2045(21)00336-3; Scopus ID: 2-s2.0-85113412076

 (Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H) J Clin Invest 2021 Aug 16;131(16). PMID: 34255748; PMCID: PMC8363288; Scopus ID: 2-s2.0-85113146308 

 (Sun F, Cheng Y, Riordan JD, Dupuy A, Dubois W, Pisano M, Dong J, Mock B, Zhan F, Hari P, Janz S) J Hematol Oncol 2021 Dec 07;14(1):203. PMID: 34876184; PMCID: PMC8650373; Scopus ID: 2-s2.0-85120899924 

(Palma FR, Ratti BA, Paviani V, Coelho DR, Miguel R, Danes JM, Zaichik SV, de Abreu AL, Silva SO, Chen Y, Silverstein RL, Karan U, Jones DP, Bonini MG) Oncogene 2021 Sep;40(36):5455-5467. PMID: 34290400; PMCID: PMC8669831; DOI: 10.1038/s41388-021-01943-x; Scopus ID: 2-s2.0-85110982210