果冻影院

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Anesthesiology
Hongwei Yu, MD

Hongwei Yu, MD

Professor

Contact Information

Education

MD, Binzhou Medical College, Binzhou, China
MS, Shandong University Medical School, Jinan, China
Postdoctoral training, Medical University of South Carolina, Charleston, SC

Research Interests

Gene and molecular therapy for chronic pain

Publications

  • (Mikesell AR, Isaeva E, Schulte ML, Menzel AD, Sriram A, Prahl MM, Shin SM, Sadler KE, Yu H, Stucky CL.) Sci Transl Med. 2024 Dec 11;16(777):eadn5629 PMID: 39661703 SCOPUS ID: 2-s2.0-85211969507 12/11/2024

  • (Tang C, Zhang H, Border JJ, Liu Y, Fang X, Jefferson JR, Gregory A, Johnson C, Lee TJ, Bai S, Sharma A, Shin SM, Yu H, Roman RJ, Fan F.) Geroscience. 2024 Jun;46(3):3135-3147 PMID: 38200357 PMCID: PMC11009215 SCOPUS ID: 2-s2.0-85182225045 01/11/2024

  • (Shin SM, Itson-Zoske B, Fan F, Xiao Y, Qiu C, Cummins TR, Hogan QH, Yu H.) J Clin Invest. 2024 May 09;134(13) PMID: 38722683 PMCID: PMC11213509 SCOPUS ID: 2-s2.0-85197962514 05/10/2024

  • (Fang X, Tang C, Zhang H, Border JJ, Liu Y, Shin SM, Yu H, Roman RJ, Fan F.) GeroScience. June 2023;45(3):1471-1490 SCOPUS ID: 2-s2.0-85150306159 06/01/2023

  • (Shin SM, Itson-Zoske B, Fan F, Gani U, Rahman M, Hogan QH, Yu H.) Mol Pain. 2023;19:17448069231174315 PMID: 37247618 PMCID: PMC10240879 SCOPUS ID: 2-s2.0-85160467897 05/30/2023

  • (Shin SM, Lauzadis J, Itson-Zoske B, Cai Y, Fan F, Natarajan GK, Kwok WM, Puopolo M, Hogan QH, Yu H.) Pain. 2022 Dec 01;163(12):2466-2484 PMID: 35420557 PMCID: PMC9562599 SCOPUS ID: 2-s2.0-85134128027 04/15/2022

  • (Itson-Zoske B, Shin SM, Xu H, Qiu C, Fan F, Hogan QH, Yu H.) Arthritis Res Ther. 2022 Jul 16;24(1):168 PMID: 35842727 PMCID: PMC9287929 SCOPUS ID: 2-s2.0-85134262185 07/17/2022

  • (Wang S, Jiao F, Border JJ, Fang X, Crumpler RF, Liu Y, Zhang H, Jefferson J, Guo Y, Elliott PS, Thomas KN, Strong LB, Urvina AH, Zheng B, Rijal A, Smith SV, Yu H, Roman RJ, Fan F.) Am J Physiol Heart Circ Physiol. 2022 Feb 01;322(2):H246-H259 PMID: 34951541 PMCID: PMC8759958 SCOPUS ID: 2-s2.0-85123651378 12/25/2021

  • (Shin SM, Moehring F, Itson-Zoske B, Fan F, Stucky CL, Hogan QH, Yu H.) Pain. 2021 Nov 01;162(11):2750-2768 PMID: 34285153 PMCID: PMC8526381 SCOPUS ID: 2-s2.0-85119089549 07/22/2021

  • (Jiao F, Varghese K, Wang S, Liu Y, Yu H, Booz GW, Roman RJ, Liu R, Fan F.) J Cardiovasc Pharmacol. 2021 Jun 01;77(6):728-734 PMID: 34001724 PMCID: PMC8169546 SCOPUS ID: 2-s2.0-85107318930 05/19/2021

  • (Liu Y, Zhang H, Wang S, Guo Y, Fang X, Zheng B, Gao W, Yu H, Chen Z, Roman RJ, Fan F.) Am J Physiol Heart Circ Physiol. 2021 Feb 01;320(2):H549-H562 PMID: 33306445 PMCID: PMC8082790 SCOPUS ID: 2-s2.0-85100362190 12/12/2020

  • (Shin SM, Cai Y, Itson-Zoske B, Qiu C, Hao X, Xiang H, Hogan QH, Yu H.) Mol Pain. 2020;16:1744806920963807 PMID: 33054557 PMCID: PMC7570798 SCOPUS ID: 2-s2.0-85092743914 10/16/2020

Publications of from the
Our research focuses are on designing, cloning, production, and application of recombinant adeno-associated viral (AAV) vectors to manipulate genes of interests in vivo in the peripheral sensory nervous system for studying pain molecular mechanism and for treating chronic pain. Directed by Dr. Quinn Hogan, we have successfully developed AAV vectors for mechanistic research and translational development. These AAV vectors have high transduction efficiency for all sensory neuron subtypes or have selective tropism to large-sized Aβ low-threshold mechanoreceptors when delivered into dorsal root ganglia (DRG) in rodent. We have recently defined a novel strategy, AAV-encoded interfering peptide aptamers (AAV-iPAs), for reversing pain by modulating the pain interactome in the peripheral nervous system. We have demonstrated the efficacy of AAV-iPAs approach using iPA targeting various TRP and voltage-gated calcium channels. We are also developing other AAV systems (AAV-targeted Optogenetics, AAV-siRNA in vivo gene knockdown, and vectors that can reconstitute transgene across synaptic partners in the first sensory synapses).

Satellite glial cells (SGCs) wrapping the primary sensory neurons together compose of unique anatomical and functional sensory units in the DRG. We recently develop a SGC-specific AAV vector (sgcAAV) that is effective in providing SGC-selective transgene expression following intraganglionic sgcAAV delivery in adult rats, and we also developed a microglia-specific AAV vector (mgAAV) by using the promoter of Iba1 gene that is a canonical microglial marker. These glial cell-targeting AAV strategies should prove useful for the development of gene expression systems targeting SGC and microglial signaling for chronic pain. We have also established a dual AAV strategy using two AAV vectors enabling efficient expression of transgenes selectively in neurons versus SGCs.

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