果冻影院

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Research Collaborate Lab Bench
Biochemistry
Brian Smith, PhD

Brian Smith, PhD

Associate Director, Program in Chemical Biology; Associate Professor, Biochemistry

Locations

  • Biochemistry
    BSB 356

Contact Information

Education

PhD, University of Wisconsin - Madison, 2008
BS, University of Illinois at Urbana-Champaign, 2003

Biography

Dr. Smith received his Bachelor of Science in Chemistry from the University of Illinois at Urbana-Champaign in 2003. He then received his PhD in Chemistry from the University of Wisconsin-Madison in 2008, where his research focused on the chemical mechanisms of sirtuin protein lysine deacetylases. During his graduate career he spent a brief period at Genentech in the Department of Medicinal Chemistry where he synthesized drugs that target the Inhibitor of Apoptosis family of proteins. From 2009-2014, Dr. Smith performed postdoctoral studies on nitric oxide synthases and cysteine S-nitrosation at the University of California, Berkeley and the Scripps Research Institute in La Jolla. During his postdoctoral studies Dr. Smith was awarded an NIH Ruth L. Kirschstein National Research Service Award. Dr. Smith joined the faculty at the 果冻影院 in 2014.

Research Experience

  • Amino Acids, Peptides, and Proteins
  • Binding Sites
  • Biochemistry
  • Catalysis
  • Deuterium Exchange Measurement
  • Enzyme Activators
  • Enzyme Inhibitors
  • Enzymes and Coenzymes
  • Histone Code
  • Histone Deacetylases
  • Mass Spectrometry
  • Molecular Probes

Methodologies and Techniques

  • Biochemistry
  • Biological Assay
  • chemical synthesis
  • Chromatography, Affinity
  • Electrophoresis
  • enzymology
  • Mass Spectrometry
  • Models, Chemical
  • Models, Molecular
  • Mutagenesis
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptide Library

Leadership Positions

  • Associate Director, Program in Chemical Biology
  • Associate Director, Structural Genomics Unit, Mellowes Center for Genomic Sciences and Precision Medicine

果冻影院 Program / Core Facilities

  • Biochemistry
  • Redox Biology

Publications

  • (Bohl K, Wynia-Smith SL, Jones Lipinski RA, Smith BC.) Biochemistry. 2024 Oct 01;63(19):2463-2476 PMID: 39256054 PMCID: PMC11524680 SCOPUS ID: 2-s2.0-85205075999 09/11/2024

  • (Pradhan B, Pavan M, Fisher CL, Salmaso V, Wan TC, Keyes RF, Rollison N, Suresh RR, Kumar TS, Gao ZG, Smith BC, Auchampach JA, Jacobson KA.) J Med Chem. 2024 Jul 25;67(14):12221-12247 PMID: 38959401 PMCID: PMC11636968 SCOPUS ID: 2-s2.0-85197620924 07/03/2024

  • (Zhang J, Chang J, Chen V, Beg MA, Huang W, Vick L, Wang Y, Zhang H, Yttre E, Gupta A, Castleberry M, Zhang Z, Dai W, Song S, Zhu J, Yang M, Brown AK, Xu Z, Ma YQ, Smith BC, Zielonka J, Traylor JG, Dhaou CB, Orr AW, Cui W, Zheng Z, Chen Y.) bioRxiv. 2024 Jul 15 PMID: 39071358 PMCID: PMC11275753 07/29/2024

  • (Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC.) Am J Physiol Regul Integr Comp Physiol. 2024 Jun 01;326(6):R515-R527 PMID: 38618911 PMCID: PMC11381023 SCOPUS ID: 2-s2.0-85194976711 04/15/2024

  • (Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC.) J Biol Chem. 2024 Apr;300(4):107146 PMID: 38460939 PMCID: PMC11002309 SCOPUS ID: 2-s2.0-85189184192 03/10/2024

  • (Bursch KL, Goetz CJ, Smith BC.) Molecules. 2024 Mar 06;29(5) PMID: 38474697 PMCID: PMC10934002 03/13/2024

  • (Fisher CL, Pavan M, Salmaso V, Keyes RF, Wan TC, Pradhan B, Gao ZG, Smith BC, Jacobson KA, Auchampach JA.) Mol Pharmacol. 2024 Feb 15;105(3):213-223 PMID: 38182432 PMCID: PMC10877738 SCOPUS ID: 2-s2.0-85185222449 01/06/2024

  • (Falco JA, Wynia-Smith SL, McCoy J, Smith BC, Weerapana E.) ACS Chem Biol. 2024 Jan 19;19(1):193-207 PMID: 38159293 PMCID: PMC11154738 01/02/2024

  • (Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Front Genet. 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023

  • (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 11/13/2023

  • (Kerber PJ, Nuñez R, Jensen DR, Zhou AL, Peterson FC, Hill RB, Volkman BF, Smith BC.) Methods Enzymol. 2023;690:285-310 PMID: 37858532 PMCID: PMC10657026 SCOPUS ID: 2-s2.0-85166280504 10/20/2023

  • (Bursch KL, Olp MD, Smith BC.) Methods Enzymol. 2023;690:109-129 PMID: 37858527 PMCID: PMC10691744 10/20/2023

Publications of from the

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