果冻影院

果冻影院
果冻影院 果冻影院
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Cell Biology, Neurobiology and Anatomy (CBNA)
Allison-Ebert

Allison D. Ebert, PhD

Associate Professor; Director, Neuroscience Doctoral Program

Locations

  • Cell Biology, Neurobiology & Anatomy

Contact Information

Education

PhD, Northwestern University, Chicago, IL, 2005
BS, Indiana University, Bloomington, IN 1999

Research Areas of Interest

  • Alzheimer Disease
  • Amyotrophic Lateral Sclerosis
  • Astrocytes
  • Cell Survival
  • Cytomegalovirus
  • Induced Pluripotent Stem Cells
  • Microglia
  • Motor Neurons
  • Muscular Atrophy, Spinal
  • Neurodegenerative Diseases
  • Organoids
  • Stem Cell Transplantation

Research Interests

Therapeutic uses of stem cells and disease modeling for spinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson’s disease, and muscular dystrophy

neurons differentiated from human embryonic stem cellsMy research interests are in the area of neurodegenerative diseases, both understanding the molecular basis for the disease progression and finding effective experimental therapies. My current research focuses on using induced pluripotent stem cells (iPSCs) derived from patient tissue to understand disease mechanisms and therapeutic intervention. One project in my lab is investigating the cell death processes involved in motor neuron loss in spinal muscular atrophy (SMA). We are using iPSCs derived from SMA patients to generate motor neurons and astrocytes to determine how the motor neurons are. My lab has found that astrocytes are dysfunctional in SMA, so we are investigating the mechanisms by which they contribute to disease pathology including alterations in secreted proteins and microRNAs. My lab also uses gene therapy and cell transplantation as potential therapeutic strategies for SMA. The second project is investigating the mechanisms underlying motor neuron loss in amyotrophic lateral sclerosis (ALS). We are using patient-specific iPSCs to assess protein aggregation in common and rare genetic forms of ALS. We incorporate gene editing techniques to create specific iPSCs for differentiation into motor neurons, astrocytes, and skeletal muscle. The third project is evaluating the effect of the G2019S LRRK2 mutation on mitochondrial trafficking and cytoskeletal structure in iPSC-derived dopamine neurons and sensory neurons. We have found the same mutation induces different consequences depending on the cell type being examined, so we are now using live cell imaging to determine mitochondrial and vesicular motility in an effort to correlate neuron-specific defects to disease phenotypes. Finally, we are examining the secretome and microRNA profile of dystrophin deficient iPSC-derived myocytes to identify novel therapeutic targets to treat muscular dystrophy.

Publications

  • (Slick RA, Sutton J, Haberman M, O'Brien BS, Tinklenberg JA, Mardikar A, Prom MJ, Beatka M, Gartz M, Vanden Avond MA, Siebers E, Mack DL, Gonzalez JP, Ebert AD, Nagaraju K, Lawlor MW.) Biol Open. 2024 Sep 15;13(9) PMID: 39158383 PMCID: PMC11391821 08/19/2024

  • (Allison RL, Welby E, Ehlers V, Burand A, Isaeva O, Nieves Torres D, Highland J, Brandow AM, Stucky CL, Ebert AD.) Blood. 2024 May 16;143(20):2037-2052 PMID: 38427938 PMCID: PMC11143522 SCOPUS ID: 2-s2.0-85189689054 03/01/2024

  • (Allison RL, Ebert AD.) Hum Mol Genet. 2024 Feb 28;33(6):530-542 PMID: 38129120 SCOPUS ID: 2-s2.0-85186709230 12/22/2023

  • (Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) mBio. 2023 Dec 19;14(6):e0225123 PMID: 37966250 PMCID: PMC10746155 SCOPUS ID: 2-s2.0-85183165409 11/15/2023

  • (Miller N, Xu Z, Quinlan KA, Ji A, McGivern JV, Feng Z, Shi H, Ko CP, Tsai LH, Heckman CJ, Ebert AD, Ma YC.) Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2300308120 PMID: 37976261 PMCID: PMC10666147 SCOPUS ID: 2-s2.0-85177422314 11/17/2023

  • (O'Brien BS, Mokry RL, Schumacher ML, Rosas-Rogers S, Terhune SS, Ebert AD.) J Virol. 2023 Oct 31;97(10):e0069623 PMID: 37796129 PMCID: PMC10653813 SCOPUS ID: 2-s2.0-85175819477 10/05/2023

  • (Kim JK, Jha NN, Awano T, Caine C, Gollapalli K, Welby E, Kim SS, Fuentes-Moliz A, Wang X, Feng Z, Sera F, Takeda T, Homma S, Ko CP, Tabares L, Ebert AD, Rich MM, Monani UR.) Neuron. 2023 May 03;111(9):1423-1439.e4 PMID: 36863345 PMCID: PMC10164130 SCOPUS ID: 2-s2.0-85150290633 03/03/2023

  • (Welby E, Ebert AD.) Glia. 2023 May;71(5):1311-1332 PMID: 36655314 SCOPUS ID: 2-s2.0-85146442117 01/20/2023

  • (Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) bioRxiv. 2023 Mar 06 PMID: 36945635 PMCID: PMC10028818 03/23/2023

  • (Allison RL, Burand A, Torres DN, Brandow AM, Stucky CL, Ebert AD.) bioRxiv. 2023 Jan 10 PMID: 36711992 PMCID: PMC9882050 01/31/2023

  • (Luecke IW, Lin G, Santarriaga S, Scaglione KM, Ebert AD.) Gene Therapy. June 2023;30(6):528-533 SCOPUS ID: 2-s2.0-85109959996 06/01/2023

  • (Mokry RL, O'Brien BS, Adelman JW, Rosas S, Schumacher ML, Ebert AD, Terhune SS.) J Virol. 2022 Jul 27;96(14):e0012622 PMID: 35862705 PMCID: PMC9327702 SCOPUS ID: 2-s2.0-85135227929 07/22/2022

Publications of from the
ebertlab2016

Ebert Lab

Lab alumni

, Assistant Professor, Department of Biochemistry, Lakeland College, Sheboygan, WI

Teresa Patitucci, PhD, Assistant Professor in Cell Biology, Neurobiology & Anatomy, 果冻影院

, Study Director at , Raleigh-Durham, North Carolina

, Associate Medical Writing Document Manager, Astellas Pharma US, Chicago, IL