John D. McCorvy, PhD

Associate Professor

Locations

Cell Biology, Neurobiology & Anatomy

Contact Information

Education

Postdoctoral, Pharmacology, University of NC-Chapel Hill, 2018
PhD, Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2012
BA, Biochemistry and Psychology, Texas Tech University, 2005

Research Interests

Molecular and Structural Pharmacology of G protein-coupled Receptors (GPCRs)
Structure-based Design and Discovery of GPCR Drugs
Study of Biased Agonism and Pathway-Selective Compounds for GPCRs
Psychedelic Drug Action at the Serotonin GPCRs
Molecular Determinants of Opioid Receptor Signaling and Efficacy
Medicinal Chemistry and Structure-Activity Relationships for Psychoactive Drugs
Antipsychotic Polypharmacology
High-throughput Screening (HTS) Technologies and Assay Development
Protein Conformation Dynamics and Structure Determination

(Alberto-Silva AS, Hemmer S, Bock HA, da Silva LA, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH.) J Neurochem. 2024 Sep;168(9):2022-2042 PMID: 38898705 PMCID: PMC11449655 SCOPUS ID: 2-s2.0-85196430944 06/20/2024
(Denomme N, Hernandez CC, Bock HA, Ohana RF, Bakshi S, Sherwood AM, McCorvy JD, Daley PF, Callaway WB, Hull JM, Alt A, Isom LL, Cozzi NV.) Mol Pharmacol. 2024 Jul 17;106(2):92-106 PMID: 38821630 PMCID: PMC11254453 SCOPUS ID: 2-s2.0-85199223647 06/01/2024
(Schlimgen RR, Peterson FC, Heukers R, Smit MJ, McCorvy JD, Volkman BF.) Nat Commun. 2024 May 30;15(1):4611 PMID: 38816420 PMCID: PMC11139983 SCOPUS ID: 2-s2.0-85194992751 05/31/2024
(Alberto-Silva AS, Hemmer S, Bock HA, Alves da Silva L, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH.) bioRxiv. 2024 Apr 11 PMID: 38645142 PMCID: PMC11030374 04/22/2024
(Kelly TJ, Bonniwell EM, Mu L, Liu X, Hu Y, Friedman V, Yu H, Su W, McCorvy JD, Liu QS.) Neuropsychopharmacology. 2024 Apr;49(5):854-863 PMID: 37752222 PMCID: PMC10948882 SCOPUS ID: 2-s2.0-85172244117 09/27/2023
(Rodriguez P, Laskowski LJ, Pallais JP, Bock HA, Cavalco NG, Anderson EI, Calkins MM, Razzoli M, Sham YY, McCorvy JD, Bartolomucci A.) J Biol Chem. 2024 Jan;300(1):105549 PMID: 38072064 PMCID: PMC10796979 SCOPUS ID: 2-s2.0-85181819143 12/11/2023
(Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD.) Nat Commun. 2023 Dec 15;14(1):8221 PMID: 38102107 PMCID: PMC10724237 SCOPUS ID: 2-s2.0-85179903706 12/16/2023
(Cameron LP, Benetatos J, Lewis V, Bonniwell EM, Jaster AM, Moliner R, Castrén E, McCorvy JD, Palner M, Aguilar-Valles A.) J Neurosci. 2023 Nov 08;43(45):7472-7482 PMID: 37940583 PMCID: PMC10634557 SCOPUS ID: 2-s2.0-85176431720 11/09/2023
(Tosh DK, Calkins MM, Ivancich MS, Bock HA, Campbell RG, Lewicki SA, Chen E, Gao ZG, McCorvy JD, Jacobson KA.) Eur J Med Chem. 2023 Nov 05;259:115691 PMID: 37562117 PMCID: PMC10529765 SCOPUS ID: 2-s2.0-85166945754 08/11/2023
(Sanchez-Reyes OB, Zilberg G, McCorvy JD, Wacker D.) J Biol Chem. 2023 Sep;299(9):105176 PMID: 37599003 PMCID: PMC10514560 SCOPUS ID: 2-s2.0-85171147748 08/21/2023
(Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL.) Cell Rep. 2023 Aug 29;42(8):112935 PMID: 37540598 PMCID: PMC10530419 SCOPUS ID: 2-s2.0-85169503465 08/04/2023
(Tosh DK, Calkins MM, Ivancich MS, Bock HA, Campbell RG, Lewicki SA, Chen E, Gao ZG, McCorvy JD, Jacobson KA.) European Journal of Medicinal Chemistry. 5 November 2023;259 SCOPUS ID: 2-s2.0-85166945754 11/05/2023

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