Matthew B. Veldman, PhD

Assistant Professor

Locations

Cell Biology, Neurobiology & Anatomy

Contact Information

Education

Scientist, UCLA, Prof. William Yang鈥檚 Laboratory, 2018
Postdoctoral Fellow, UCLA, Prof. Shuo Lin鈥檚 Laboratory, 2014
PhD, Neuroscience, University of Michigan, 2007
BS, Biochemistry, University of Minnesota, 1999

Biography

Dr. Veldman earned his PhD in Neuroscience at the University of Michigan in the Laboratory of Daniel Goldman studying the mechanisms of successful optic nerve regeneration in the zebrafish model organism. His studies were first to describe the importance of the KLF family of transcription factors, specifically KLF6 and KLF7, in nerve regeneration. This was followed by postdoctoral training in cardiovascular developmental biology in Shuo Lin’s laboratory at UCLA where he studied the endothelial cell fate transcription factor Etsrp/Etv2 and discovered its ability to transdifferentiate skeletal muscle cells into endothelial cells and drive endothelial cell differentiation from human embryonic stem cells. While in the Lin Laboratory, he developed an inducible Huntington’s disease model in zebrafish in collaboration with X. William Yang’s laboratory that highlighted the protective role of the N17 domain of huntingtin protein Exon 1 fragment. Dr. Veldman then joined the Yang laboratory to develop novel reporter mouse lines for sparse, genetically defined cell labeling to study cell morphology. The technology developed for this project, Mosaicism with Repeat Frameshift (MORF), is a powerful tool for labeling and manipulating sparse cells in vivo. These experiences have focused Dr. Veldman’s scientific interests on development, degeneration, and regeneration in the central nervous system and developing new genetic tools to study these processes.

Research Areas of Interest

Animals
Animals, Genetically Modified
Blood Vessels
Brain
Brain Mapping
Cells, Cultured
Disease Models, Animal
Electrophoretic Mobility Shift Assay
Embryo, Nonmammalian
Gene Expression Profiling
Gene Expression Regulation
Gene Expression Regulation, Developmental

Research Interests

Our research is broadly interested in basic mechanisms of development, degeneration, and regeneration in the central nervous system with the goal of applying this knowledge to treat patients suffering from neurodevelopmental or neurodegenerative conditions, or traumatic brain injuries. We use systems biology approaches and genetic screens to identify genes and pathways involved in the processes being studied and then use molecular-genetic and pharmacological tools, and new technologies to tease out targets for therapeutic intervention. Our initial focus is on applying modern molecular biological methods (such as CRISPR-Cas9, RNA-seq, ATAC-seq, etc.) to study the cell intrinsic and extrinsic mechanisms of successful optic nerve regeneration in the zebrafish visual system and compare these mechanisms to those in mammals, which fail to regenerate and suffer from degeneration.

(Akins KA, Flinn MA, Swift SK, Chanjeevaram SV, Purdy AL, Buddell T, Kolell ME, Andresen KG, Paddock S, Buday SL, Veldman MB, O'Meara CC, Patterson M.) Am J Physiol Heart Circ Physiol. 2024 Aug 01;327(2):H377-H389 PMID: 38847758 PMCID: PMC11442100 SCOPUS ID: 2-s2.0-85199812831 06/07/2024
(Veldman MB, Bhattacharya SK.) J Ocul Pharmacol Ther. 2023 Oct;39(8):473 PMID: 37861411 SCOPUS ID: 2-s2.0-85174864803 10/20/2023
(Hu M, Veldman MB.) J Ocul Pharmacol Ther. 2023 Oct;39(8):563-571 PMID: 37486664 PMCID: PMC10616938 SCOPUS ID: 2-s2.0-85167663680 07/24/2023
(Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, RReSTORe Consortium, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV.) Mol Neurodegener. 2023 Sep 21;18(1):64 PMID: 37735444 PMCID: PMC10514988 SCOPUS ID: 2-s2.0-85171956125 09/22/2023
(Eisa-Beygi S, Hu MM, Kumar SN, Jeffery BE, Collery RF, Vo NJ, Lamichanne BS, Yost HJ, Veldman MB, Link BA.) Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):e231-e237 PMID: 37128914 PMCID: PMC10330147 SCOPUS ID: 2-s2.0-85163499929 05/02/2023
(Meehan SD, Hu M, Veldman MB, Bhattacharya SK.) Data Brief. 2023 Jun;48:109102 PMID: 37383800 PMCID: PMC10293924 06/29/2023
(Meehan SD, Hu M, Veldman MB, Bhattacharya SK.) Data in Brief. June 2023;48 SCOPUS ID: 2-s2.0-85154023596 06/01/2023
(Speer W, Veldman MB.) Methods Mol Biol. 2023;2636:311-321 PMID: 36881308 SCOPUS ID: 2-s2.0-85149523514 03/08/2023
(BRAIN Initiative Cell Census Network (BICCN).) Nature. 2021 Oct;598(7879):86-102 PMID: 34616075 PMCID: PMC8494634 SCOPUS ID: 2-s2.0-85116508250 10/08/2021
(Peng H, Xie P, Liu L, Kuang X, Wang Y, Qu L, Gong H, Jiang S, Li A, Ruan Z, Ding L, Yao Z, Chen C, Chen M, Daigle TL, Dalley R, Ding Z, Duan Y, Feiner A, He P, Hill C, Hirokawa KE, Hong G, Huang L, Kebede S, Kuo HC, Larsen R, Lesnar P, Li L, Li Q, Li X, Li Y, Li Y, Liu A, Lu D, Mok S, Ng L, Nguyen TN, Ouyang Q, Pan J, Shen E, Song Y, Sunkin SM, Tasic B, Veldman MB, Wakeman W, Wan W, Wang P, Wang Q, Wang T, Wang Y, Xiong F, Xiong W, Xu W, Ye M, Yin L, Yu Y, Yuan J, Yuan J, Yun Z, Zeng S, Zhang S, Zhao S, Zhao Z, Zhou Z, Huang ZJ, Esposito L, Hawrylycz MJ, Sorensen SA, Yang XW, Zheng Y, Gu Z, Xie W, Koch C, Luo Q, Harris JA, Wang Y, Zeng H.) Nature. 2021 Oct;598(7879):174-181 PMID: 34616072 PMCID: PMC8494643 SCOPUS ID: 2-s2.0-85116413344 10/08/2021
(Arcuri J, Veldman MB, Bhattacharya SK.) Data Brief. 2021 Aug;37:107260 PMID: 34377754 PMCID: PMC8327136 08/12/2021
(Veldman MB, Park CS, Eyermann CM, Zhang JY, Zuniga-Sanchez E, Hirano AA, Daigle TL, Foster NN, Zhu M, Langfelder P, Lopez IA, Brecha NC, Zipursky SL, Zeng H, Dong HW, Yang XW.) Neuron. 2020 Oct 14;108(1):111-127.e6 PMID: 32795398 PMCID: PMC7572760 SCOPUS ID: 2-s2.0-85090058615 08/17/2020

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