Yiliang Chen

Yiliang Chen, PhD

Assistant Professor

Locations

Versiti Blood Research Institute,
Room 235

Contact Information

General Interests

Metabolism, Immunology

Education

PhD, Medical College of Ohio, 2009
MS, National University of Singapore, Singapore, 2004
BS, Fudan University, China, 2001

Learn more about the Yiliang Chen Laboratory

Biography

Secondary Appointments

Biochemistry

Dr. Chen received his Bachelor of Science degree in Genetics from Fudan University (China) in 2001 and his Doctorate degree from the University of Toledo (USA) in 2009, where he studied cholesterol metabolisms and signal transduction. He pursued his postdoctoral work at Blood Center of Wisconsin, Blood Research Institute, where he worked on the functions of a scavenger receptor CD36 and its role in chronic inflammation and atherosclerosis. Dr. Chen joined the 果冻影院 faculty in 2020 as an Assistant Professor in the Department of Medicine. He is also a member of 果冻影院’s Cardiovascular Center. Dr. Chen has a life-long passion in the study of metabolic diseases that are often associated with oxidative stress, abnormal lipid metabolism and chronic inflammation.

Honors and Awards

2012 ATVB
2012 Travel Award for Young Investigators
2008 Retiree鈥檚 Scholarship Award Winner, University of Toledo
2004-2009 Pre-Doctoral Fellowship, University of Toledo
2002-2004 Research Fellowship, National University of Singapore, Singapore

Research Interests

We are interested in a chronic inflammatory disease called atherosclerosis, which is the leading cause of death in the developed countries. Atherosclerosis is characterized by atherosclerotic plaques in the medium and large arteries and the major components of the plaques are lipid-laden innate immune cells called macrophages. Using a variety of genetically modified mice as in vivo animal models together with in vitro cell culture model and many biochemical techniques, we study the molecular mechanisms underlying the pro-atherogenic functions of the macrophages.

We are also using novel state-of-the-art technologies including single cell RNA sequencing, high resolution confocal microscopy, Seahorse extracellular flux metabolic assays, GC-MS, and so on to explore cell expression network that are linked to immune activation and metabolic status. With these novel tools, we are able to study not only the macrophage functions but also the cross talk between macrophage and other cell types.

Laboratory Studies

How CD36-mediated signaling and the fatty acid trafficking influence macrophage immune activation?
How does mitochondria integrate lipid signals and other metabolic signals to determine its function (e.g. oxidative phosphorylation vs. ROS production)?
How does macrophage communicate with adipocytes under atherogenic conditions, which facilitate chronic inflammation?

(Wolfe JT, Chen V, Chen Y, Tefft BJ.) J Thorac Cardiovasc Surg. 2024 Jul 05 PMID: 38972570 SCOPUS ID: 2-s2.0-85200217289 07/08/2024
(Huang M, Wang X, Chen Y, Pessoa MT, Terrell KC, Zhang J, Tian J, Xie Z, Pierre SV, Cai L.) Am J Physiol Cell Physiol. 2024 Jul 01;327(1):C48-C64 PMID: 38708522 PMCID: PMC11371328 SCOPUS ID: 2-s2.0-85196920218 05/06/2024
(Beg MA, Huang M, Vick L, Rao KNS, Zhang J, Chen Y.) Trends Pharmacol Sci. 2024 Apr;45(4):290-303 PMID: 38458847 SCOPUS ID: 2-s2.0-85187360123 03/09/2024
(Hou Y, Tan E, Shi H, Ren X, Wan X, Wu W, Chen Y, Niu H, Zhu G, Li J, Li Y, Wang L.) Cell Mol Life Sci. 2024 Jan 11;81(1):23 PMID: 38200266 PMCID: PMC10781825 SCOPUS ID: 2-s2.0-85181875396 01/11/2024
(Chen V, Zhang J, Chang J, Beg MA, Vick L, Wang D, Gupta A, Wang Y, Zhang Z, Dai W, Kim M, Song S, Pereira D, Zheng Z, Sodhi K, Shapiro JI, Silverstein RL, Malarkannan S, Chen Y.) Front Cardiovasc Med. 2024;11:1436865 PMID: 39156133 PMCID: PMC11327822 SCOPUS ID: 2-s2.0-85201434395 08/19/2024
(Aljadah M, Khan N, Beyer AM, Chen Y, Blanker A, Widlansky ME.) JACC: Advances. August 2024;3(8) SCOPUS ID: 2-s2.0-85197318304 08/01/2024
(Mukherji ST, Brambilla L, Stuart KB, Mayes I, Kutz LC, Chen Y, Barbosa LA, Elmadbouh I, McDermott JP, Haller ST, Romero MF, Soleimani M, Liu J, Shapiro JI, Blanco GV, Xie Z, Pierre SV.) FASEB J. 2023 Apr;37(4):e22835 PMID: 36856735 PMCID: PMC10028530 SCOPUS ID: 2-s2.0-85149427345 03/02/2023
(Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z.) Research and Practice in Thrombosis and Haemostasis. August 2023;7(6) SCOPUS ID: 2-s2.0-85169507694 08/01/2023
(Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y.) Front Cardiovasc Med. 2023;10:1046495 PMID: 37180782 PMCID: PMC10174328 SCOPUS ID: 2-s2.0-85159873988 05/14/2023
(Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022
(Chen Y, Zhang J, Cui W, Silverstein RL.) J Exp Med. 2022 Jun 06;219(6) PMID: 35438721 PMCID: PMC9022290 SCOPUS ID: 2-s2.0-85128794972 04/20/2022
(Zhang J, Dai W, Chen Y.) Front Cardiovasc Med. 2022;9:938535 PMID: 35811702 PMCID: PMC9257247 07/12/2022

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