果冻影院

果冻影院
果冻影院 果冻影院
Research Bench Lab
Microbiology & Immunology
Kenneth Brockman, PhD

Kenneth L. Brockman, PhD

Assistant Professor

Locations

  • Microbiology & Immunology
    BSB | Office: B2935, Lab: B2620

Contact Information

General Interests

Microbial Pathogenesis, Bacterial Gene Regulation, Host-Microbe Interactions

Education

PhD, Microbiology, Electron Microscopy, University of Wisconsin Milwaukee, Milwaukee, WI, 2014
Learn more about the Brockman Lab

Research Experience

  • Achromobacter
  • Adhesins, Bacterial
  • Bacteria
  • Bacteria, Anaerobic
  • Biofilms
  • Chinchilla
  • Cystic Fibrosis
  • Haemophilus Infections
  • Macrophages
  • Mucus
  • Neutrophils
  • Otitis Media

Methodologies and Techniques

  • Biofilms
  • Chinchilla
  • Disease Models, Animal
  • DNA Modification Methylases
  • Epigenomics
  • Mice
  • Mutation
  • Primary Cell Culture
  • Real-Time Polymerase Chain Reaction
  • Sequence Analysis, RNA

Research Interests

My primary research is focused on defining the role of a novel regulatory system, the phasevarion, in the pathogenesis of diseases caused by several human pathogens which include, Haemophilus influenzae, Moraxella catharrhalis, Helicobacter pylori and Neisseria species. I have a specific interest in the phasevarion of nontypeable Haemophilus influenzae (NTHi), which causes otitis media, sinusitis, exacerbations of disease in the lungs of those with cystic fibrosis and chronic obstructive pulmonary disease, and multiple other diseases of both the upper and lower respiratory tracts. The phasevarion is especially fascinating because in contrast to typical phase variation, in which expression of only a single gene is affected, the phasevarion affects the expression of many genes throughout the bacterial chromosome via the phase variation of a single gene, modA. We have investigated the role of the phasevarion in numerous disease-related processes, which include in vitro biofilm formation, adherence to primary respiratory epithelial cells, resistance to innate immune cell killing and extensive animal modeling. My group utilizes murine and chinchilla models of disease, including bacterial only and bacterial-viral co-infections. The overarching goal of my research is better understand the complexities of microbial-host interactions and delineate key factors that contribute to persistence and disease, with the ultimate goal of developing novel approaches for treatment and prevention.

Publications

  • (Huss NP, Majeed ST, Wills BM, Tarakanova VL, Brockman KL, Jondle CN.) Virology. 2024 Sep;597:110153 PMID: 38941745 PMCID: PMC11257779 SCOPUS ID: 2-s2.0-85196778582 06/29/2024

  • (Atack JM, Brockman KL, Bakaletz LO, Jennings MP.) Microbiol Resour Announc. 2023 Dec 14;12(12):e0078523 PMID: 37991358 PMCID: PMC10720539 11/22/2023

  • (Wills BM, Garai P, Dickinson Q, Meyer JG, Brockman KL.) iScience. 2023 Oct 20;26(10):107785 PMID: 37727736 PMCID: PMC10505976 09/20/2023

  • (Wills BM, Garai P, Riegert MO, Sanchez FT, Pickrum AM, Frank DW, Brockman KL.) Infect Immun. 2023 Jul 18;91(7):e0003723 PMID: 37255468 PMCID: PMC10353400 SCOPUS ID: 2-s2.0-85165519693 05/31/2023

  • (Garai P, Atack JM, Wills BM, Jennings MP, Bakaletz LO, Brockman KL.) Microbiol Spectr. 2023 Feb 14;11(1):e0409322 PMID: 36511712 PMCID: PMC9927368 SCOPUS ID: 2-s2.0-85148113631 12/14/2022

  • (Wills BM, Garai P, Dickinson Q, Meyer JG, Brockman KL.) iScience. 20 October 2023;26(10) SCOPUS ID: 2-s2.0-85170435505 10/20/2023

  • (Pickrum AM, Riegert MO, Wells C, Brockman K, Frank DW.) Microbiol Spectr. 2022 Aug 31;10(4):e0208322 PMID: 35856670 PMCID: PMC9430717 SCOPUS ID: 2-s2.0-85137137821 07/21/2022

  • (Phillips ZN, Garai P, Tram G, Martin G, Van Den Bergh A, Husna AU, Staples M, Grimwood K, Jennison AV, Guillon P, von Itzstein M, Jennings MP, Brockman KL, Atack JM.) Infect Immun. 2022 Apr 21;90(4):e0056521 PMID: 35258316 PMCID: PMC9022572 SCOPUS ID: 2-s2.0-85128634430 03/09/2022

  • (Atack JM, Day CJ, Poole J, Brockman KL, Timms JRL, Winter LE, Haselhorst T, Bakaletz LO, Barenkamp SJ, Jennings MP.) mBio. 2020 Nov 03;11(6) PMID: 33144377 PMCID: PMC7642680 SCOPUS ID: 2-s2.0-85095613918 11/05/2020

  • (Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL.) Front Cell Infect Microbiol. 2020;10:512743 PMID: 33194779 PMCID: PMC7644868 SCOPUS ID: 2-s2.0-85095581955 11/17/2020

  • (Robledo-Avila FH, Ruiz-Rosado JdD, Partida-Sanchez S, Brockman KL.) Frontiers in Cellular and Infection Microbiology. 23 October 2020;10 SCOPUS ID: 2-s2.0-85095581955 10/23/2020

  • (Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S.) Front Immunol. 2020;11:97 PMID: 32117251 PMCID: PMC7010865 SCOPUS ID: 2-s2.0-85079677223 03/03/2020

Publications of from the