果冻影院

Research Bench Lab
Scott Terhune, PhD

Scott S. Terhune, PhD

Professor

Locations

  • Microbiology & Immunology
    TBRC C2890

Contact Information

General Interests

Human Cytomegalovirus Host-Cell Protein Interactions During Infection

Education

PhD, Cancer Biology, Northwestern University, 2000
Postdoctoral Fellow, Proteomics/Cytomegalovirus Biology, Princeton University, 2007

Research Areas of Interest

  • Alzheimer's Disease
  • Cell Cycle
  • Cell Differentiation
  • Cytomegalovirus
  • Host-Pathogen Interactions
  • Neuropathogenesis
  • Proteomics
  • Viral Proteins
  • Virus Replication

Research Experience

  • Antiviral Agents
  • Cell Cycle
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cytomegalovirus
  • Histone Acetyltransferases
  • Histone Deacetylases
  • Host-Pathogen Interactions
  • Protein Kinases
  • Signal Transduction
  • STAT3 Transcription Factor
  • Tumor Suppressor Protein p53

Methodologies and Techniques

  • Cell Cycle
  • DNA, Viral
  • Drug Synergism
  • Protein Interaction Mapping
  • Proteomics
  • RNA, Viral
  • Virus Replication

Leadership Positions

  • Past Chair, Faculty Career Development Committee
  • Scientific Advisor, AHW
  • SOM and Graduate School Rank Committees

Research Interests

Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.

Publications

  • (Womack JA, Shah V, Audi SH, Terhune SS, Dash RK.) Bioinform Adv. 2024;4(1):vbae023 PMID: 38456125 PMCID: PMC10918630 SCOPUS ID: 2-s2.0-85187381144 03/08/2024

  • (Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) mBio. 2023 Dec 19;14(6):e0225123 PMID: 37966250 PMCID: PMC10746155 SCOPUS ID: 2-s2.0-85183165409 11/15/2023

  • (O'Brien BS, Mokry RL, Schumacher ML, Rosas-Rogers S, Terhune SS, Ebert AD.) J Virol. 2023 Oct 31;97(10):e0069623 PMID: 37796129 PMCID: PMC10653813 SCOPUS ID: 2-s2.0-85175819477 10/05/2023

  • (Shah V, Womack J, Zamora AE, Terhune SS, Dash RK.) Annu Int Conf IEEE Eng Med Biol Soc. 2023 Jul;2023:1-5 PMID: 38083755 SCOPUS ID: 2-s2.0-85179638579 12/12/2023

  • (Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F.) PLoS Pathog. 2023 Jun;19(6):e1011185 PMID: 37289831 PMCID: PMC10284425 SCOPUS ID: 2-s2.0-85163920856 06/08/2023

  • (Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) bioRxiv. 2023 Mar 06 PMID: 36945635 PMCID: PMC10028818 03/23/2023

  • (Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M, Meier JL, Hummel M.) Microbiol Spectr. 2023 Feb 14;11(1):e0314422 PMID: 36645269 PMCID: PMC9927211 SCOPUS ID: 2-s2.0-85148092420 01/17/2023

  • (Shah V, Womack J, Zamora AE, Terhune SS, Dash RK.) ArXiv. 2023 Feb 08 PMID: 36798455 PMCID: PMC9934731 02/18/2023

  • (Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F.) bioRxiv. 2023 Feb 07 PMID: 36798153 PMCID: PMC9934528 02/18/2023

  • (Monti CE, Mokry RL, Schumacher ML, Dash RK, Terhune SS.) Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2201787119 PMID: 35994667 PMCID: PMC9437303 SCOPUS ID: 2-s2.0-85136192098 08/23/2022

  • (Mokry RL, O'Brien BS, Adelman JW, Rosas S, Schumacher ML, Ebert AD, Terhune SS.) J Virol. 2022 Jul 27;96(14):e0012622 PMID: 35862705 PMCID: PMC9327702 SCOPUS ID: 2-s2.0-85135227929 07/22/2022

  • (O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD.) iScience. 2022 Apr 15;25(4):104098 PMID: 35391828 PMCID: PMC8980761 04/09/2022