Peter J. Newman, PhD

Professor; Vice President for Research, Versiti Blood Center of Wisconsin; Associate Director, Blood Research Institute

Locations

Pharmacology and Toxicology

Contact Information

Research Interests

Central to the ability of vascular cells to adhere to the extracellular matrix and to each other is an abundant supply of cell surface adhesion molecules that, in addition to influencing the adhesive phenotype of the cell, are also capable of transmitting signals into, and responding to signals from, the cell interior (often referred to an outside/in and inside/out signal transduction, respectively). Such post-ligand events occur by virtue of the ability of these transmembrane proteins to interact with intracellular kinases and phosphatases, G-proteins, adapter proteins, and cytoskeletal components. Our laboratory divides its attention between exploring the role of stimulatory and inhibitory receptors in regulating adhesion and aggregation of human and murine platelets (funded through a Program Project grant), and the structure and function of PECAM-1 in the blood and vascular cells in which it is expressed (funded through a long-standing R01). Techniques range from biochemistry to molecular biology to whole animal models of thrombosis and hemostasis.

Current Grant Support

NIH Grant R01 HL40926, years 22-26 - Molecular Biology and Function of PECAM-1
NIH Program Project Grant P01-HL44612, years 21-25 (Program Director, Leader, Project 1, and Director of Administrative Core A) - Molecular Mechanisms of Platelet Activation and Adhesion
NIH Postdoctoral Training Grant HL-07209 (Co-PI with GC White)

Ongoing NIH-funded research projects

Molecular mechanisms of integrin signaling
Integrin/ITAM coupling in platelets and vascular cells
Role of PECAM-1 adhesion and signaling in endothelial cell barrier function and vascular permeability
Construction of transgenic and knock-in mice expressing variant forms of PECAM-1
In vitro microfluidic models of thrombus formation

(Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ.) J Biol Chem. 2016 Dec 09;291(50):26216-26225 PMID: 27793989 PMCID: PMC5207088 SCOPUS ID: 2-s2.0-85002858868 10/30/2016
(Dai B, Wu P, Xue F, Yang R, Yu Z, Dai K, Ruan C, Liu G, Newman PJ, Gao C.) Thromb Haemost. 2016 Oct 28;116(5):918-930 PMID: 27465472 SCOPUS ID: 2-s2.0-84994571270 10/30/2016
(Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ.) Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1517-24 PMID: 27283740 PMCID: PMC5140275 SCOPUS ID: 2-s2.0-84973532000 06/11/2016
(Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman PJ.) Curr Opin Hematol. 2016 May;23(3):253-9 PMID: 27055047 PMCID: PMC4986701 SCOPUS ID: 2-s2.0-84963651443 04/08/2016
(Paddock C, Zhou D, Lertkiatmongkol P, Newman PJ, Zhu J.) Blood. 2016 Feb 25;127(8):1052-61 PMID: 26702061 PMCID: PMC4768429 SCOPUS ID: 2-s2.0-84960356253 12/25/2015
(Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ.) Blood. 2016 Feb 11;127(6):675-80 PMID: 26634302 PMCID: PMC4751021 SCOPUS ID: 2-s2.0-84959330331 12/05/2015
(Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ.) PLoS One. 2015;10(8):e0135738 PMID: 26291522 PMCID: PMC4546160 SCOPUS ID: 2-s2.0-84942901879 08/21/2015
(Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman PJ, Wang D, Newman DK.) PLoS One. 2015;10(3):e0119739 PMID: 25793864 PMCID: PMC4368822 SCOPUS ID: 2-s2.0-84925859948 03/21/2015
(Mei H, Campbell JM, Paddock CM, Lertkiatmongkol P, Mosesson MW, Albrecht R, Newman PJ.) J Biol Chem. 2014 Jul 25;289(30):20836-44 PMID: 24936065 PMCID: PMC4110291 SCOPUS ID: 2-s2.0-84905407842 06/18/2014
(Privratsky JR, Newman PJ.) Cell Tissue Res. 2014 Mar;355(3):607-19 PMID: 24435645 PMCID: PMC3975704 SCOPUS ID: 2-s2.0-84899440750 01/18/2014
(Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ.) Blood. 2013 Oct 10;122(15):2732-42 PMID: 23926302 PMCID: PMC3795464 SCOPUS ID: 2-s2.0-84888251628 08/09/2013
(Bakchoul T, Greinacher A, Sachs UJ, Krautwurst A, Renz H, Harb H, Bein G, Newman PJ, Santoso S.) Blood. 2013 Jul 18;122(3):321-7 PMID: 23645838 PMCID: PMC3716199 SCOPUS ID: 2-s2.0-84879304669 05/07/2013

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