Matt Durand, PhD
Associate Professor; Research Director; Secondary Faculty Appointment in Physiology
Locations
- Cardiovascular Center
MEB, M4845
Contact Information
Education
PhD, Physiology, 果冻影院, 2010
Postdoctoral Training, 果冻影院, 2015
Biography
Dr. Durand received his PhD from the Department of Physiology at the 果冻影院 in 2010 under the mentorship of Dr. Julian Lombard. He then chose to continue his training at 果冻影院 and completed his postdoctoral fellowship under the mentorship of Dr. David Gutterman in the Department of Medicine. In 2015 Dr. Durand joined the faculty in the Department of Physical Medicine and Rehabilitation at 果冻影院.
Research Experience
- Angiotensin II
- Endothelium-Dependent Relaxing Factors
- Exercise
- Exercise Therapy
- Frailty
- Hypertension
- Ischemic Postconditioning
- Ischemic Preconditioning
- Mitochondria
- Nitric Oxide
- Prehabilitation
- Stroke
Leadership Positions
- Research Director - Department of Physical Medicine and Rehabilitation
果冻影院 Program / Core Facilities
- Cardiovascular Center
Research Interests
My research focus is a blend of exercise physiology, vascular biology, and rehabilitation science. Stroke is the leading cause of disability in adults in the United States. Post-stroke, many individuals experience profound muscle weakness due to decreased neural activation of the muscle. Other factors can also contribute to muscle weakness and enhanced muscle fatigability however, including lack of adequate blood flow to exercising skeletal muscle. The Durand lab, in collaboration with Dr. Allison Hyngstrom’s laboratory from the Department of Physical Therapy at Marquette University, has shown that blood flow to the exercising paretic muscle is dramatically reduced in stroke survivors compared to age-matched controls. We have also shown that a non-invasive, cost-effective, simple intervention called ischemic conditioning can increase blood flow to the exercising muscle, while also increasing paretic muscle strength and reducing neuromuscular fatigability. Current projects are examining how ischemic conditioning can improve muscle performance and blood flow to exercising muscle in stroke survivors, including by modulating a fundamental physiological process that allows blood vessels in an active muscle bed to remain vasodilated during exercise, called functional sympatholysis. Another area of interest in the Durand laboratory is the concept of microvascular resiliency. Frailty is defined as a state of increased vulnerability to stress. This is a major concern to our healthcare systems as our population is aging and upwards of 50% of adults in the US who require surgery are considered frail. How the microvasculature responds to external stressors in elderly individuals remains largely unknown. Current projects in collaboration with Dr. Julie Freed from the Department of Anesthesiology are examining how the microvasculature responds differently to high intensity interval exercise stress in elderly individuals with high vs. low cardiorespiratory fitness. We are further examining whether ischemic conditioning can improve this stress response in the elderly, and whether ischemic conditioning is a suitable “prehabilitation” intervention in elderly individuals who require surgery.
Publications
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(Hyngstrom AS, Nguyen JN, Wright MT, Tarima SS, Schmit BD, Gutterman DD, Durand MJ.) J Appl Physiol (1985). 2020 Dec 01;129(6):1348-1354 PMID: 33090908 PMCID: PMC7792845 SCOPUS ID: 2-s2.0-85097570561 10/23/2020
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(Patel JJ, Baruah D, Sobush D, Koester K, Aase J, Zellner S, Graf J, Durand MJ, Szabo A, Shahir K.) Nutr Clin Pract. 2020 Feb;35(1):133-141 PMID: 31172570 PMCID: PMC10515294 SCOPUS ID: 2-s2.0-85067355654 06/07/2019
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(Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM.) Cardiovasc Res. 2019 Aug 01;115(10):1546-1556 PMID: 30476208 PMCID: PMC6648341 SCOPUS ID: 2-s2.0-85072658081 11/27/2018
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(Durand MJ, Boerger TF, Nguyen JN, Alqahtani SZ, Wright MT, Schmit BD, Gutterman DD, Hyngstrom AS.) J Appl Physiol (1985). 2019 Mar 01;126(3):755-763 PMID: 30653420 PMCID: PMC6459385 SCOPUS ID: 2-s2.0-85063648049 01/18/2019
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(Murphy S, Durand M, Negro F, Farina D, Hunter S, Schmit B, Gutterman D, Hyngstrom A.) Front Physiol. 2019;10:545 PMID: 31133877 PMCID: PMC6524339 SCOPUS ID: 2-s2.0-85068235791 05/28/2019
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(Hyngstrom AS, Murphy SA, Nguyen J, Schmit BD, Negro F, Gutterman DD, Durand MJ.) J Appl Physiol (1985). 2018 May 01;124(5):1140-1147 PMID: 29420152 PMCID: PMC6050199 SCOPUS ID: 2-s2.0-85047752851 02/09/2018
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(Kadlec AO, Barnes C, Durand MJ, Gutterman DD.) Am J Hypertens. 2018 Jan 12;31(2):240-246 PMID: 29140431 PMCID: PMC5861535 SCOPUS ID: 2-s2.0-85040822121 11/16/2017
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(Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD.) Hypertension. 2017 Jul;70(1):166-173 PMID: 28533333 PMCID: PMC5485836 SCOPUS ID: 2-s2.0-85019610110 05/24/2017
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(Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD.) Am J Physiol Heart Circ Physiol. 2017 May 01;312(5):H1096-H1104 PMID: 28213406 PMCID: PMC5451582 SCOPUS ID: 2-s2.0-85019633788 02/19/2017
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(Durand MJ, Ait-Aissa K, Gutterman DD.) Circ Res. 2017 Apr 28;120(9):1379-1380 PMID: 28450357 SCOPUS ID: 2-s2.0-85019623537 04/30/2017
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(Buchanan CE, Kadlec AO, Hoch AZ, Gutterman DD, Durand MJ.) Med Sci Sports Exerc. 2017 Apr;49(4):669-675 PMID: 27824690 PMCID: PMC5357152 SCOPUS ID: 2-s2.0-84994589876 11/09/2016
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(Durand, Matthew J., Buchanan, Cullen E., Hoch, Anne Z., Gutterman, David D..) Medicine & Science in Sports & Exercise. Durand, Matthew J., Buchanan, Cullen E., Hoch, Anne Z., Gutterman, David D.Does Barostress On The Endothelium During Maximal Exertion Cause Endothelial Dysfunction In Healthy, Sedentary Subjects? Medicine & Science in Sports & Exercise, 2016, 5(48). 05/01/2016