果冻影院

header-logo
Research Lab Bench
Physiology
Justin L. Grobe, PhD, FAHA

Justin L. Grobe, PhD, FAHA, FAPS

Professor, Physiology & Biomedical Engineering; Butenhoff Family Professor of Cardiovascular Research; Director, Comprehensive Rodent Metabolic Phenotyping Core

Locations

  • Physiology
    HRC 4875

Contact Information

Education

Postdoc, Internal Medicine & Pharmacology, University of Iowa, Iowa City, IA, 2006-2010
PhD, Pharmacodynamics, University of Florida, Gainesville, FL, 2006
BS, Biology; BA, Chemistry, Hope College, Holland, MI, 2001

Biography

Justin L. Grobe, PhD, moved to the 果冻影院’s Department of Physiology in June 2019. He holds a secondary appointment in the Department of Biomedical Engineering, and serves as the founding director of the Comprehensive Rodent Metabolic Phenotyping Core facility. Before joining the faculty at 果冻影院, Dr. Grobe was a tenured associate professor in the Department of Pharmacology at the University of Iowa.

Research Areas of Interest

  • Adiposity
  • Agouti-Related Protein
  • Arcuate Nucleus of Hypothalamus
  • Basal Metabolism
  • Blood Pressure
  • Body Composition
  • Body Water
  • Body Weight
  • Brain
  • Central Nervous System
  • Dehydration
  • Disease Models, Animal

Research Experience

  • Arginine Vasopressin
  • Blood Pressure
  • Energy Metabolism
  • Gastrointestinal Microbiome
  • Hypertension
  • Hypothalamus
  • Obesity
  • Pre-Eclampsia
  • Pregnancy
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Water-Electrolyte Balance

Methodologies and Techniques

  • Analysis of Variance
  • Basal Metabolism
  • Calorimetry
  • Dose-Response Relationship, Drug
  • Eating
  • Energy Metabolism
  • Feeding Behavior
  • Humans
  • Mice
  • Rats
  • Sensitivity and Specificity
  • Statistics

Leadership Positions

  • Co-Course Director, 果冻影院 INBS 16245 Statistics for Basic Sciences
  • Director, 果冻影院 Comprehensive Rodent Metabolic Phenotyping Core
  • Member, 果冻影院 MSTP Admissions Committee
  • Vice-Chair, 果冻影院 Institutional Animal Care & Use Committee

果冻影院 Program / Core Facilities

  • Comprehensive Rodent Metabolic Phenotyping Core

Educational Expertise

  • Basal Metabolism
  • Biostatistics
  • Energy Metabolism
  • Hypertension
  • Neurosciences
  • Pre-Eclampsia

Research Interests

Our team is focused on understanding the physiological interplay among cardiovascular and metabolic control systems. Our primary area of inquiry is the neurobiology controlling blood pressure and resting metabolic rate, which has implications for our understanding of the pathogenesis and potential treatments for obesity and obesity-associated hypertension. Our work also focuses on contributions of neuroendocrine and G protein signaling systems to the hypertensive cardiovascular disorder of pregnancy, preeclampsia. Further, we are working to develop novel techniques to quantitate anaerobic metabolism in vivo, and thereby understanding the role of the gut microbiota in energy homeostasis.

Fields of major interest:

  • Neurogenic hypertension
  • Obesity and obesity-associated hypertension
  • Hypothalamic control of blood pressure and resting metabolism
  • Cross-talk of blood pressure and metabolic rate, and selective leptin resistance
  • Water & electrolyte homeostasis
  • Renin-angiotensin system
  • Arginine vasopressin
  • Anaerobic metabolism
  • Gut microbiota
  • Development of novel calorimetry methods
  • Mathematical modeling and biostatistics

Publications

  • (Fekete ÉM, Gomez J, Ghobrial M, Kaminski K, Muskus PC, Boychuk CR, Hantke Guixa A, Vazirabad I, Xie M, Ganiyu A, Golosova D, Mathieu NM, Wang YB, Lu KT, Wackman KK, Brozoski DT, Mouradian GC, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P.) Hypertension. 2024 Dec 02 PMID: 39618396 SCOPUS ID: 2-s2.0-85210962734 12/02/2024

  • (Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL.) Am J Physiol Regul Integr Comp Physiol. 2024 Nov 16 PMID: 39548798 11/16/2024

  • (Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL.) Hypertension. 2024 Nov;81(11):2209-2217 PMID: 39315447 PMCID: PMC11483214 SCOPUS ID: 2-s2.0-85205521844 09/24/2024

  • (Wildes MP, Fernando DG, Grobe CC, Reho JJ, Grobe JL, Kidambi S, Kindel TL, Kwitek AE, Segar JL, Williams JS, Morselli LL.) Endocrinology. 2024 Aug 27;165(10) PMID: 39236000 PMCID: PMC11408931 SCOPUS ID: 2-s2.0-85204510410 09/05/2024

  • (Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD.) Hypertension. 2024 Jun;81(6):1332-1344 PMID: 38629290 PMCID: PMC11096025 SCOPUS ID: 2-s2.0-85193429264 04/17/2024

  • (Morselli LL, Amjad R, James R, Kindel TL, Kwitek AE, Williams JS, Grobe JL, Kidambi S.) J Endocr Soc. 2024 Apr 06;8(6):bvae062 PMID: 38623381 PMCID: PMC11017326 SCOPUS ID: 2-s2.0-85190716270 04/16/2024

  • (Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2024 Mar 01;326(3):R242-R253 PMID: 38284128 PMCID: PMC11213288 SCOPUS ID: 2-s2.0-85186271298 01/29/2024

  • (Lawton SB, Grobe CC, Reho JJ, Raff H, Thulin JD, Jensen ES, Burnett CM, Segar JL, Grobe JL.) J Am Assoc Lab Anim Sci. 2024 Mar 01;63(2):190-200 PMID: 38191147 PMCID: PMC11022944 SCOPUS ID: 2-s2.0-85192114074 01/09/2024

  • (Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL.) Physiol Genomics. 2024 Mar 01;56(3):265-275 PMID: 38145289 PMCID: PMC10866620 SCOPUS ID: 2-s2.0-85185200180 12/25/2023

  • (Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL.) Sci Adv. 2023 Dec;9(48):eadg8118 PMID: 38039359 PMCID: PMC10691776 SCOPUS ID: 2-s2.0-85178323055 12/01/2023

  • (Wagner VA, Holl KL, Clark KC, Reho JJ, Lehmler HJ, Wang K, Grobe JL, Dwinell MR, Raff H, Kwitek AE.) Endocrinology. 2023 Nov 02;164(12) PMID: 37882530 PMCID: PMC10637104 SCOPUS ID: 2-s2.0-85176509096 10/26/2023

  • (Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL.) Am J Physiol Regul Integr Comp Physiol. 2023 Nov 01;325(5):R576-R592 PMID: 37720996 PMCID: PMC10866575 SCOPUS ID: 2-s2.0-85174752582 09/18/2023

Publications of from the

© 2024 果冻影院.  All rights reserved.  | Terms and Privacy 

Non-Discrimination Statement
The 果冻影院 (果冻影院) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the 果冻影院 community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic. 果冻影院’s policy as well as federal and state laws and regulations prohibit unlawful discrimination and harassment.