Justin L. Grobe, PhD, FAHA, FAPS

Professor, Physiology & Biomedical Engineering; Butenhoff Family Professor of Cardiovascular Research; Director, Comprehensive Rodent Metabolic Phenotyping Core

Locations

Physiology
HRC 4875

Contact Information

Education

Postdoc, Internal Medicine & Pharmacology, University of Iowa, Iowa City, IA, 2006-2010
PhD, Pharmacodynamics, University of Florida, Gainesville, FL, 2006
BS, Biology; BA, Chemistry, Hope College, Holland, MI, 2001

Biography

Justin L. Grobe, PhD, moved to the 果冻影院’s Department of Physiology in June 2019. He holds a secondary appointment in the Department of Biomedical Engineering, and serves as the founding director of the Comprehensive Rodent Metabolic Phenotyping Core facility. Before joining the faculty at 果冻影院, Dr. Grobe was a tenured associate professor in the Department of Pharmacology at the University of Iowa.

                
                    Research Areas of Interest
                

                    Adiposity
Agouti-Related Protein
Arcuate Nucleus of Hypothalamus
Basal Metabolism
Blood Pressure
Body Composition
Body Water
Body Weight
Brain
Central Nervous System
Dehydration
Disease Models, Animal

            

                
                    Research Experience
                

                    Arginine Vasopressin
Blood Pressure
Energy Metabolism
Gastrointestinal Microbiome
Hypertension
Hypothalamus
Obesity
Pre-Eclampsia
Pregnancy
Receptors, G-Protein-Coupled
Renin-Angiotensin System
Water-Electrolyte Balance

            

                
                    Methodologies and Techniques
                

                    Analysis of Variance
Basal Metabolism
Calorimetry
Dose-Response Relationship, Drug
Eating
Energy Metabolism
Feeding Behavior
Humans
Mice
Rats
Sensitivity and Specificity
Statistics

            

                
                    Leadership Positions
                

                    Co-Course Director, 果冻影院 INDP 16245 Statistics for Basic Sciences
Director, 果冻影院 Comprehensive Rodent Metabolic Phenotyping Core
Member, 果冻影院 MSTP Admissions Committee
Vice-Chair, 果冻影院 Institutional Animal Care & Use Committee

            

                
                    果冻影院 Program / Core Facilities
                

                    Comprehensive Rodent Metabolic Phenotyping Core

            

                
                    Educational Expertise
                

                    Basal Metabolism
Biostatistics
Energy Metabolism
Hypertension
Neurosciences
Pre-Eclampsia

            

Research Interests

Our team is focused on understanding the physiological interplay among cardiovascular and metabolic control systems. Our primary area of inquiry is the neurobiology controlling blood pressure and resting metabolic rate, which has implications for our understanding of the pathogenesis and potential treatments for obesity and obesity-associated hypertension. Our work also focuses on contributions of neuroendocrine and G protein signaling systems to the hypertensive cardiovascular disorder of pregnancy, preeclampsia. Further, we are working to develop novel techniques to quantitate anaerobic metabolism in vivo, and thereby understanding the role of the gut microbiota in energy homeostasis.

Fields of major interest:

Neurogenic hypertension
Obesity and obesity-associated hypertension
Hypothalamic control of blood pressure and resting metabolism
Cross-talk of blood pressure and metabolic rate, and selective leptin resistance
Water & electrolyte homeostasis
Renin-angiotensin system
Arginine vasopressin
Anaerobic metabolism
Gut microbiota
Development of novel calorimetry methods
Mathematical modeling and biostatistics

(Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL.) Hypertension. 2024 Nov;81(11):2209-2217 PMID: 39315447 PMCID: PMC11483214 SCOPUS ID: 2-s2.0-85205521844 09/24/2024
(Wildes MP, Fernando DG, Grobe CC, Reho JJ, Grobe JL, Kidambi S, Kindel TL, Kwitek AE, Segar JL, Williams JS, Morselli LL.) Endocrinology. 2024 Aug 27;165(10) PMID: 39236000 PMCID: PMC11408931 SCOPUS ID: 2-s2.0-85204510410 09/05/2024
(Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD.) Hypertension. 2024 Jun;81(6):1332-1344 PMID: 38629290 PMCID: PMC11096025 SCOPUS ID: 2-s2.0-85193429264 04/17/2024
(Morselli LL, Amjad R, James R, Kindel TL, Kwitek AE, Williams JS, Grobe JL, Kidambi S.) J Endocr Soc. 2024 Apr 06;8(6):bvae062 PMID: 38623381 PMCID: PMC11017326 SCOPUS ID: 2-s2.0-85190716270 04/16/2024
(Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2024 Mar 01;326(3):R242-R253 PMID: 38284128 PMCID: PMC11213288 SCOPUS ID: 2-s2.0-85186271298 01/29/2024
(Lawton SB, Grobe CC, Reho JJ, Raff H, Thulin JD, Jensen ES, Burnett CM, Segar JL, Grobe JL.) J Am Assoc Lab Anim Sci. 2024 Mar 01;63(2):190-200 PMID: 38191147 PMCID: PMC11022944 SCOPUS ID: 2-s2.0-85192114074 01/09/2024
(Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL.) Physiol Genomics. 2024 Mar 01;56(3):265-275 PMID: 38145289 PMCID: PMC10866620 SCOPUS ID: 2-s2.0-85185200180 12/25/2023
(Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL.) Sci Adv. 2023 Dec;9(48):eadg8118 PMID: 38039359 PMCID: PMC10691776 SCOPUS ID: 2-s2.0-85178323055 12/01/2023
(Wagner VA, Holl KL, Clark KC, Reho JJ, Lehmler HJ, Wang K, Grobe JL, Dwinell MR, Raff H, Kwitek AE.) Endocrinology. 2023 Nov 02;164(12) PMID: 37882530 PMCID: PMC10637104 SCOPUS ID: 2-s2.0-85176509096 10/26/2023
(Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL.) Am J Physiol Regul Integr Comp Physiol. 2023 Nov 01;325(5):R576-R592 PMID: 37720996 PMCID: PMC10866575 SCOPUS ID: 2-s2.0-85174752582 09/18/2023
(Araya BR, Ziegler AA, Grobe CC, Grobe JL, Segar JL.) Newborn (Clarksville). 2023;2(2):142-147 PMID: 37614871 PMCID: PMC10445331 08/24/2023
(Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC Jr, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P.) Function (Oxf). 2023;4(5):zqad043 PMID: 37609445 PMCID: PMC10440998 SCOPUS ID: 2-s2.0-85168790693 08/23/2023

果冻影院