果冻影院

Immunology, Cell Signaling

Research Experience

果冻影院, 2024-Present
Advisor: Renren Wen, PhD

果冻影院, 2021-2022
Advisor: John McCorvy
Project: Investigated activity of novel psychedelic therapeutic compounds at GPCRs

Washington University in St. Louis, 2019
Advisor: Wayne Yokoyama/Michael Paley
Project: Inducing cytotoxicity in T-helper cells in vitro

Washington University in St. Louis, 2018-2019
Advisor: Wayne Yokoyama/Swapneel Patel
Project: Distinct roles of CD8+ T-cells in adult and neonatal murine roseolovirus infection 

Publications

Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential. Nat Commun. 2023 Dec 15;14(1):8221. doi: 10.1038/s41467-023-44016-1. PMID: 38102107; PMCID: PMC10724237.

Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Identification of 5-HT 2A Receptor Signaling Pathways Responsible for Psychedelic Potential. bioRxiv [Preprint]. 2023 Jul 31:2023.07.29.551106. doi: 10.1101/2023.07.29.551106. PMID: 37577474; PMCID: PMC10418054.

Lewis V, Bonniwell EM, Lanham JK, Ghaffari A, Sheshbaradaran H, Cao AB, Calkins MM, Bautista-Carro MA, Arsenault E, Telfer A, Taghavi-Abkuh FF, Malcolm NJ, El Sayegh F, Abizaid A, Schmid Y, Morton K, Halberstadt AL, Aguilar-Valles A, McCorvy JD. A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. Cell Rep. 2023 Mar 28;42(3):112203. doi: 10.1016/j.celrep.2023.112203. Epub 2023 Mar 6. PMID: 36884348; PMCID: PMC10112881.

Cunningham MJ, Bock HA, Serrano IC, Bechand B, Vidyadhara DJ, Bonniwell EM, Lankri D, Duggan P, Nazarova AL, Cao AB, Calkins MM, Khirsariya P, Hwu C, Katritch V, Chandra SS, McCorvy JD, Sames D. Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs. ACS Chem Neurosci. 2023 Jan 4;14(1):119-135. doi: 10.1021/acschemneuro.2c00597. Epub 2022 Dec 15. PMID: 36521179; PMCID: PMC10147382.

Orr MJ, Cao AB, Wang CT, Gaisin A, Csakai A, Friswold AP, Meltzer HY, McCorvy JD, Scheidt KA. Discovery of Highly Potent Serotonin 5-HT2 Receptor Agonists Inspired by Heteroyohimbine Natural Products. ACS Med Chem Lett. 2022 Mar 18;13(4):648-657. doi: 10.1021/acsmedchemlett.1c00694. PMID: 35450369; PMCID: PMC9014500.

Hartigan K, Alarcon JH, Cao A, Chen Y, Curnutt N, Felsheim B, Gothi S, Grandison L, McDermut M, Spight KS, Xu X, Weston-Hafer K, Shaffer C. Complete Genome Sequences of Streptomyces lividans Bacteriophages Satis and JustBecause. Microbiol Resour Announc. 2019 Aug 8;8(32):e00501-19. doi: 10.1128/MRA.00501-19. PMID: 31395631; PMCID: PMC6687918. 

General Interests

Taking care of plants and animals, swimming, exploring the outdoors, identifying bugs, attempting to play Ghibli music on the piano