果冻影院

Cancer immunotherapy, pancreatic cancer, and precision medicine

Research Experience

果冻影院, 2021-present
Advisor: Michael Dwinell, PhD
Project: The Role of CCR6 in pancreatic cancer and tregs (F30CA291095)

University of Michigan-Ann Arbor, 2016-2018
Advisor: Marina Pasca di Magliano, PhD
Project 1: Determining the role of Beta-1 integrin signaling in providing resistance to MEK inhibition in pancreatic cancer
Project 2: Elucidating the downstream targets of the Hedgehog signaling pathway in pancreatic cancer

University of Michigan-Ann Arbor, 2018-2020
Advisor: Flip Bednar, MD, PhD
Project: Identifying the targets of BMI1 in human pancreatic cancer cell lines 

Publications

Drouillard D, Craig BT, Dwinell MB. Physiology of chemokines in the cancer microenvironment. Am J Physiol Cell Physiol. 2023 Jan 1;324(1):C167-C182. doi: 10.1152/ajpcell.00151.2022. Epub 2022 Nov 1. PMID: 36317799; PMCID: PMC9829481.

AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB. Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression. iScience. 2021 May 25;24(6):102653. doi: 10.1016/j.isci.2021.102653. PMID: 34189432; PMCID: PMC8220235.

Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, et al. Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clin Cancer Res. 2021 Jan 25. doi: 10.1158/1078-0432.CCR-20-3715. Epub ahead of print. PMID: 33495315.

Brannon A 3rd, Drouillard D, Steele N, Schoettle S, Abel EV, Crawford HC, Pasca di Magliano M. Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition. Sci Rep. 2020 Jul 7;10(1):11133. doi: 10.1038/s41598-020-67814-9. PMID: 32636409; PMCID: PMC7340786.

Meeting Abstracts

Drouillard D, Volkman B, and Dwinell MB. Roles for the Chemokine Receptor CCR6 in Pancreatitis and Pancreatic Cancer. American Association of Immunologists 2024, Chicago, IL. AAI Trainee Abstract Award. [Poster and Invited Talk]

Drouillard D and Dwinell MB. CCL20 Recruits Super Suppressor CCR6+ Tregs in Gastrointestinal Malignancies. Midwest Tumor Microenvironment 2024, Madison, WI. [Poster and Invited Talk]

Donovan Drouillard, Gwen Lomberk, Raul Urrutia, Susan Tsai, Brian Volkman, and Michael B. Dwinell. Identifying the receptor for CXCL17 and characterizing its role in pancreatic ductal adenocarcinoma. Autumn Immunology Conference 2022, Chicago, IL. [Poster]

General Interests

Volleyball, running, hiking, disc golf, going to concerts, traveling, and a good Netflix binge. My favorite sports teams are the Detroit Lions and Michigan Wolverines.