Research Interests
Cancer biology, DNA damage repair, and hormone signaling
Research Experience
University of Cambridge
NIH Oxford-Cambridge Scholars Program
Co Advisors: Kathleen Kelly, PhD and Carlos Caldas, MD
Project: Targeting the DNA damage response in hormone-driven cancers
National Cancer Institute, NIH
Advisors: Ira Pastan, MD and Christine Alewine, MD, PhD
Project: Using recombinant immunotoxins against mesothelin to treat pancreatic cancer
University of Illinois at Urbana-Champaign
Advisor: Marni Boppart, ScD
Project: Investigating the [alpha]7 integrin as therapeutic targets in the prevention of age-related maladaptive changes in skeletal muscle tissue
Publications
Kolyvas EA, Caldas C, Kelly K, Ahmad S. Androgen receptor function and targeted therapeutics across breast cancer subtypes. Breast Cancer Research. 2022 Nov 14.
El-Behaedi S, Landsman R, Rudloff M, Kolyvas E, Albalawy R, Zhang X, Bera T, Collins K, Kozlov S, Alewine C. Protein synthesis inhibition activity of mesothelin targeting immunotoxin LMB-100 decreases concentrations of oncogenic signaling molecules and secreted growth factors. Toxins. 2018 Oct 31.
Huntsman HD, Rendeiro C, Merritt JR, Pincu Y, Cobert A, De Lisio M, Kolyvas E, Dvoretskiy S, Dobrucki IT, Kemkemer R, Jensen T, Dobrucki LW, Rhodes JS, Boppart MD. The impact of mechanically stimulated muscle-derived stromal cells on aged skeletal muscle. Experimental Gerontology. 2017 Dec 18.
Kolyvas EA, Rudloff M, Poruchynsky M, Landsman R, Hollevoet K, Venzon D, Alewine C. Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes. Oncotarget. 2017 Feb 7.
Kaplan G, Lee F, Onda M, Kolyvas E, Bhardwaj G, Baker D, Pastan I. Protection of the furin cleavage sequence in low-toxicity immunotoxins based on Pseudomonas exotoxin A. Toxins. 2016 Jul 25.
Meeting Abstracts
Kolyvas EA, Piscitello D, Omarjee S, Taylor HJ, Papachristou E, Manzano-Garcia R, Kelly K, Caldas C, Carroll J, O’Connor M, Ahmad S. Targeting the DNA damage response to radio-sensitize hormone-driven cancers. Poster presentation at the Hormone-Dependent Cancers Gordon Research Conference Annual Meeting, Newry, ME. 2023.
Kolyvas EA, Ahmad S, Omarjee S, Papachristou E, Manzano-Garcia R, Rueda O, Carroll J, Kelly K, Caldas C. Understanding the interaction of PTEN and androgen receptor in hormone-driven cancers. Oral presentation at the NIH Global Doctoral Partnership Programs’ Annual Research Symposium, Virtual. 2021.
Kolyvas EA, Senatorov I, Jansson K, Beshiri M, Caldas C, Kelly K. Understanding the Roles of PTEN and DNA Damage Response in the Treatment of Metastatic Prostate Cancer. Poster presentation at the NIH Global Doctoral Partnership Programs’ Annual Research Symposium, Cambridge, UK. 2019.
Kolyvas EA, Pastan I, Alewine C. Co-treatment of taxane with mesothelin targeted immunotoxin improves pancreatic cancer cell killing. Poster presentation at the NIH Research Festival. 2015.
Kolyvas EA, Alewine C. Pirfenidone co-treatment does not affect Immunotoxin efficacy. Poster presentation at the NIH Post Baccalaureate Poster Day. 2015.
General Interests
Travel, baseball (go Cubs!), cooking