果冻影院

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Education
- Medical School
  Choose from a three or four-year MD program at various campus locations, our anesthesiologist assistant, physician associate, or a number of dual degree programs.
- Residency and Fellowship Programs
  Choose from more than 140 specialties and sub-specialties for advanced medical training at 果冻影院.
- Graduate School
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- PA/NP Fellowship and Residency Programs
  Innovative 12-month PA and NP transition to practice programs in a variety of specialty clinical tracks.
- Pharmacy School
  An innovative three-year PharmD program designed for the expanding pharmacist role in patient care.
- Career Pathway Programs
  Programs that support middle school to college learners in their academic and professional journeys in medicine and biomedical science.
- Commencement
  果冻影院 Commencement Events 鈥� All Campuses
- Continuing Professional Development (CME)
  Develops applied learning experiences and supports continual education of the healthcare professional beyond graduation.
Research
- Basic Science Research
  Our scientists are discovery-drivers, working to develop cutting-edge treatments.
- Clinical trials are invaluable in testing new treatments, drugs and technologies.
- Project Wonder
  Project Wonder: the Art of Science at the 果冻影院 partners basic and translational scientists with local artists and writers to elevate and amplify their innovative, life-changing research.
- Translational scientists turn science and research into improved treatments.
- Centers
  Through collaboration with the brightest minds in science and medicine 果冻影院鈥檚 Centers are at the forefront of discovery and innovation.
- Continuing Professional Development (CME)
  Develops applied learning experiences and supports continual education of the healthcare professional beyond graduation.
Community
- Community Connection
  We have the power to advance the health and vitality of all. We invite you to reach out, connect and work with us as we strive towards this vision.
- Advancing a Healthier Wisconsin Endowment
  Through research, health care education, workforce development, and community health initiatives, AHW drives change.
- Community Engagement
  Enhancing learning, research, patient care and the health of the community.
- Continuing Professional Development (CME)
  Develops applied learning experiences and supports continual education of the healthcare professional beyond graduation.
- Institute for Health & Equity
  A hub focused on population health, biostatistics, bioethics and epidemiology research.
- Thrive On Collaboration
  Imagine a Milwaukee that is equitable, healthy and thriving for all.
Giving
- Advance Research
  We鈥檙e driving research that leads to improved diagnoses, more effective treatments, and new cures.
- Create Healthier Communities
  We work closely with partners to redefine health beyond healthcare and with a bold vision of achieving health equity for all.
- Healthcare Education
  We鈥檙e committed to meeting the needs of our changing population, and solving the significant healthcare provider shortage.
- Annual Fund For Excellence
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Find a Doctor

MSTP students in the Sahoo lab

Medical Scientist Training Program

Nicholas Malcolm

M3 Student

Faculty Advisor

John McCorvy, PhD, and Jonathan Marchant, PhD, Cell Biology, Neurobiology & Anatomy

Locations

Medical Scientist Training Program

Contact Information

nmalcolm@mcw.edu

Education

BS, Mathematics, Molecular Biology, University of Wisconsin-Parkside, 2018

Research Interests

Computational biology, drug discovery, statistical mechanics, protein dynamics and chronic pain

Research Experience

果冻影院, 2020-2024
Advisor: John McCorvy, PhD
Project: Investigating The Molecular Determinants Of Superagonism At The Mu-Opioid Receptor

果冻影院, 2017
Advisor: Jeffrey Medin, PhD
Project: Mitochondrial activity in mouse models of lysosomal storage disorders

UW - Parkside, 2016-2017
Advisor: Daphne Pham, PhD
Project: Inhibitors of ribonucleotide reductase oligomerization as a novel mosquito control mechanism

Publications

Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD. Mu-opioid receptor selective superagonists produce prolonged respiratory depression. iScience. 2023 Jun 13;26(7):107121. doi: 10.1016/j.isci.2023.107121. PMID: 37416459; PMCID: PMC10320493.

Lewis V, Bonniwell EM, Lanham JK, Ghaffari A, Sheshbaradaran H, Cao AB, Calkins MM, Bautista-Carro MA, Arsenault E, Telfer A, Taghavi-Abkuh FF, Malcolm NJ, El Sayegh F, Abizaid A, Schmid Y, Morton K, Halberstadt AL, Aguilar-Valles A, McCorvy JD. A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. Cell Rep. 2023 Mar 28;42(3):112203. doi: 10.1016/j.celrep.2023.112203. Epub 2023 Mar 6. PMID: 36884348; PMCID: PMC10112881.

Rohr CM, Sprague DJ, Park SK, Malcolm NJ, Marchant JS. Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2217732120. doi: 10.1073/pnas.2217732120. Epub 2022 Dec 27. PMID: 36574686; PMCID: PMC9910428.

Meeting Abstracts

Malcolm N, Palkovic B, Sprague D, Cavalco N, Calkins M, Lanham J, et al. Markovian Modeling of the Conformational Dynamics Involved in Âµ-Opioid Receptor Superagonism. Complexity in Proteins Gordon Research Conference (GRC); Holderness, NH. Jun 2023. [Poster]

General Interests

Reading, tabletop games, miniature figurine painting, heavy metal, dogs, and horses