果冻影院

header-logo
Physicians Hall Front
果冻影院 Newsroom

果冻影院 Researcher Highlights a Potentially Novel Therapy for Treating Postoperative Pain

The opioid epidemic touches the lives of most Americans. Opioid-related overdoses took the lives of more than 47,000 people in 2017, and 36 percent of those deaths were contributable to prescription opioids. [1] Current statistics show that approximately 80 percent of surgical patients experience acute postoperative pain, and of these patients, 74 percent of them will continue to experience extreme pain after discharge. [2,3]

Many of these opioid prescriptions are given to patients to ease their pain after undergoing surgery or other operations involving incisions. Postoperative pain has both inflammatory and neuropathic qualities and this in part is why postoperative pain is difficult to treat.

Preliminary research conducted by Dr. Ashley Cowie during her PhD candidacy at the 果冻影院 demonstrated that a protein complex of the innate immune system, the NLRP3 inflammasome, drives the development and maintenance of postoperative pain in a sex-dependent manner. The study was highlighted as the Editor’s Choice article in the research journal PAIN and is accompanied by a video abstract of the findings. It explained that among the 9 known inflammasomes, the NLRP3 inflammasome is ideally positioned to drive postoperative pain through interleukin-1β production, an inflammatory cytokine of the innate immune system, because NLRP3 can be activated by factors that are released by incision. While conducting her study, she found that the deletion of NLRP3 decreased the intensity and duration of postoperative pain in male, but not female, mice. The study concludes by stating that this is the first evidence of a key role for NLRP3 in postoperative pain and reveals immune-mediated sex differences in postoperative pain.

This study highlights a potentially novel therapy to further explore and possibly, one day, holds the key to treating postoperative pain without the use of prescription opioids.

Ashley Cowie Ashley Cowie, PhD

Sources:

[1] Scholl L, Seth P, Karisa M, Wilson N, Baldwin G. Drug and Opioid-Involved Overdose Deaths – United States, 2013-2017. ().
[2] Chapman CR, Vierck CJ. The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms. ()
[3] Gan TJ, Habib AS, Miller TE, White W, Apfelbaum JL. Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey. ()

© 2024 果冻影院.  All rights reserved.  | Terms and Privacy 

Non-Discrimination Statement
The 果冻影院 (果冻影院) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the 果冻影院 community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic. 果冻影院’s policy as well as federal and state laws and regulations prohibit unlawful discrimination and harassment.