Research | Pediatrics Hematology Oncology & Bone Marrow Transplant

果冻影院 Pediatric Hematology/Oncology/Blood and Marrow Transplant Research

The Division of Hematology/Oncology/Blood and Marrow has a long-standing commitment to basic and translation research that stems from the work carried out in our basic science laboratories, participation in co-operative group trials, as well as in epidemiology and outcomes research

Meet Our Research Faculty

Kristin Bingen, PhD

鈥淢y research interests include psychosocial functioning and health-related quality of life of childhood cancer survivors of adolescents and young adults, as well as transitional care of adolescents and young adults with cancer.鈥�

Amanda Brandow, DO

“My clinical research lab is focused on investigating the underlying neurobiology of pain in patients with sickle cell disease. My interest in pain research has also expanded beyond sickle cell disease to studying neuropathic pain in children with cancer who have received neurotoxic chemotherapy.”

Meghen Browning, MD

鈥淢y research interests include novel local control modalities for sarcoma, adolescent and young adult sarcoma care, and cellular therapies for solid tumors, especially neuroblastoma.鈥�

Michael J. Burke, MD

My research interests are focused on the development of early phase clinical trials involving novel agents and/or combination therapies for relapsed/refractory hematologic neoplasms.”

William Drobyski, MD

“My research interests focus on the immunobiology of allogeneic stem cell transplantation. Specifically, I am interested in the pathophysiology of graft versus host disease, pro inflammatory cytokine dysregulation, the immunotherapy of cancer, and immune reconstitution.”

Veronica Flood, MD

“My research is focused on the coagulation protein von Willebrand factor and its interactions with ligands, including platelets and collagen. My laboratory studies the molecular biology of von Willebrand factor, with an interest in mutations and sequence variations, and their effect on protein function.”

Paul Harker-Murray, MD, PhD

“My research interests are in clinical trials of pediatric patients with relapsed and refractory Hodgkin lymphoma; nanoliposomal irinotecan and cyclophosphamide for relapsed solid tumors; and quality improvement in pediatric hematology, oncology, bone marrow transplant.”

Jennifer Hoag, PhD

“My research interests include family adjustment, psychosocial outcomes of bone marrow/peripheral stem cell donation, and school re-integration.”

David A. Margolis, MD

鈥淢y research interests are focused on the treatment of children with severe aplastic anemia as well as allogeneic hematopoietic progenitor cell transplant for children with malignant and non-malignant disorders.鈥�

Jeffrey A. Medin, PhD

"My research is focused on ameliorating acquired and inherited disorders by way of gene therapy. My laboratory develops novel chimeric antigen receptor and bispecific antibody-based immunotherapies and studies the pathophysiology and treatment of inherited monogenic diseases."

Learn more about the Medin Lab below.

Robert Montgomery, MD

“My research interests are: clinical and molecular studies on 650 subject USA VWD cohort; tests to define VWF functions; gene therapy of hemophilia; a through ectopic expression of FVIII in platelets; and the role of VWF pathology in cardiopulmonary bypass in neonates with complex congenital heart disease.”

Rowena Punzalan, MD

鈥淢y research interests are in pediatric thrombosis and anticoagulation, and pediatric transfusion medicine.鈥�

Sridhar Rao, MD, PhD

“The overall goal of my laboratory is to understand how transcription factors and epigenetic pathways regulate the unique properties of stem cells, whether they are embryonic stem cells, adult stem cells, or cancer stem cells.”

Qizhen Shi, MD, PhD

“My research interest is in hemophilia.”

Fritz Sieber, PhD

“My research interests are in preclinical development of novel selenium-based anti-cancer agents with emphasis on proteinated subnano particles of elemental selenium. Selenium-based interventions for the prevention and mitigation of therapy-induced toxicities with emphasis on radiation- and chemotherapy-induced hearing loss and cognitive defects.”

Julie-An Talano, MD

“My research interests are in alternative bone marrow transplantation for hematologic malignancies and non-malignant disorders and Phase I Cytotoxic T cells for immune reconstitution post transplantation. I am currently the Director of Clinical Research in Bone Marrow Transplantation.”

Richard L. Tower, II, MD, MS

“My research interest is in the effects of leukemia therapies, communication with patients and families, and medical education.”

David Wilcox, PhD

“My research interests are in hematopoietic stem cell gene therapy aimed using platelets to correct inherited bleeding disorder. The goal of my research is to utilize hematopoietic stem cells as a target for gene therapy for common and rare inherited bleeding disorders.“

About Pediatric Hematology/Oncology Research

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Basic Research Faculty

Veronica H. Flood, MD - coagulation defects and von Willebrand disease.

Jill Gershan, PhD - development of cell-based vaccine for the treatment of breast cancer and breast cancer stem cells.

Joan C. Gill, MD - molecular and clinical biology of von Willebrand disease, coumadin pharmacogenetics in children, immunology of inhibitor formation in hemophilia, T-cell responses to hepatitis C synthetic peptides in HCV-infected hemophilic patients, replacement therapy in hemophilia.

Sandra L. Haberichter, PhD - cell biology and molecular mechanisms of von Willebrand disease.

Bryon Johnson, PhD - bone marrow transplantation, immune memory, immune therapy for cancer, pediatric malignancies, neuroblastoma, tumor vaccines.

Robert R. Montgomery, MD - molecular and clinical biology of VWD, gene therapy of hemophilia.

Qizhen Shi, MD, PhD - hemophilia, the association between VWF and FVIII, gene therapy, immune response in hemophilia gene therapy.

Fritz Sieber, PhD - development of novel anti-cancer agents, prevention, and mitigation of damage to normal tissue in patients undergoing radiation therapy.

Other Resources

Research Affiliations

The and the Pediatric Hematology/Oncology/Blood and Marrow Transplant Division at the 果冻影院 have an ongoing collaboration that has contributed to an invaluable network of scientific discovery and patient care.

The is a combined research program of the National Marrow Donor Program and the 果冻影院 working to collect and study data on blood and bone marrow transplants worldwide. More than 500 international transplant centers collaborate with the CIBMTR to conduct research studies, collect, maintain, and share outcomes data on more than 300,000 transplant recipients, provide statistical expertise to researchers, and to provide education, guidelines, and training.

The advances state-of-the-art pediatric health care through translational research programs to find life-saving discoveries and cures in the disease that affect children and interventions that enhance quality of life for children and families living with chronic health conditions.

The Clinical Immunodiagnostic and Research Laboratory (CIRL) provides comprehensive diagnostic services and innovative methods to detect, diagnose, and treat immunologic, hematologic, and oncologic disease states.

The 果冻影院 Cancer Center is the only academic-based cancer research and patient care group in Southeastern Wisconsin. It is a matrix cancer center with clinical facilities at Froedtert Hospital, Children's Wisconsin, and Zablocki VA Medical Center.

The , a Milwaukee based charitable organization, works very closely with the Pediatric Hematology/Oncology/Blood and Marrow Transplant Division and the 果冻影院 to fight pediatric cancer and related blood disorders through research funding. Since its inception in 1976, the MACC Fund has contributed nearly $30 million to the College’s pediatric cancer and blood disorder research. This unique and exceptional affiliation provides researchers in the resources needed to fight against childhood cancer and related blood disorders.

Jeffrey A. Medin, PhD Research Lab

果冻影院 | Department of Pediatrics: Section of Hematology/Oncology/BMT

Contact the Medin Lab

Jeffrey A Medin, PhD

Professor, Pediatrics (Hematology/Oncology); Secondary Faculty

jmedin@mcw.edu
(414) 955-4118

Mary Faber, PhD

Lab Manager

mfaber@mcw.edu
(414) 955-5771